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dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.6 mL | 42.98 mL | 85.96 mL |
| 0.5 mM | 1.72 mL | 8.6 mL | 17.19 mL |
| 1 mM | 0.86 mL | 4.3 mL | 8.6 mL |
| 5 mM | 0.17 mL | 0.86 mL | 1.72 mL |
*The above data is based on the productmolecular weight 1163.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18378 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 1163.3 |
| Formula | C61H66N10O12S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2351218-88-5 |
| SMILES | O=S(N(CC1)CCN1C(C=C2)=CC=C2OCC3=C(C4=C(N(CCN5CCN(C(COC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)CC5)C(C(O)=O)=C9CCCOC%10=C(C=CC=C%11)C%11=CC=C%10)C9=CC=C4)C(C)=NN3C)(N(C)C)=O |
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