DNA Damage
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Camptothecin
Catalog No. A10174 -
Epirubicin HCl
Catalog No. A10345 Topoisomerase II 抑制剂Epirubicin HCl是一种可透过细胞的蒽环类抗肿瘤抗生素。它用于抑制拓扑异构酶II和DNA解旋酶活性。 了解更多 -
Mitoxantrone
Catalog No. A10595 Mitoxantrone是一种合成的抗肿瘤药蒽二酮(IC50 = 0.42 mM)。 了解更多 -
Balofloxacin
Catalog No. A11658 Topoisomerase 抑制剂Balofloxacin是一种喹诺酮类抗生素。Balofloxacin的杀菌作用源于对细菌DNA合成所需的酶DNA促旋酶的干扰。Balofloxacin对革兰氏阴性菌有效。它还对革兰氏阳性细菌(包括MRSA和肺炎链球菌)具有增强的活性。 了解更多 -
Sarafloxacin HCl
Catalog No. A11659 Topoisomerase 抑制剂Sarafloxacin hydrochloride是氟喹诺酮类抗菌剂。抑制细菌DNA促旋酶(拓扑异构酶)。 了解更多 -
Pefloxacin mesylate
Catalog No. A11902 Pefloxacin mesylate是一种合成化学治疗剂和抗菌剂,IC50值为6.7 nM。 了解更多 -
(S)-10-Hydroxycamptothecin
Catalog No. A11997 Topoisomerase(S)-10-Hydroxycamptothecin是喜树碱衍生物,它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。 了解更多 -
Betulinic acid
Catalog No. A11999 Betulinic acid是天然存在的五环三萜,具有抗逆转录病毒,抗疟疾和抗炎特性。 了解更多 -
Podophyllotoxin
Catalog No. A10740 Podophyllotoxin是微管装配的有效抑制剂,可在微管蛋白的秋水仙碱部位结合。 了解更多 -
Mitoxantrone Hydrochloride
Catalog No. A10596 Mitoxantrone Dihydrochloride是一种抗病毒,抗菌,抗原生动物,免疫调节和抗肿瘤细胞抑制性蒽醌衍生物。 了解更多 -
Pirarubicin
Catalog No. A10735 Topoisomerase II 抑制剂Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II(拓扑异构酶II)相互作用并抑制DNA复制。 了解更多 -
Flumequine
Catalog No. A11861 Topoisomerase II 抑制剂Flumequine是一种合成化学抗生素,可在回旋酶/拓扑异构酶水平上影响哺乳动物染色体和DNA的解链。抑制拓扑异构酶II, IC50为15 μM。 了解更多 -
Amrubicin
Catalog No. A12663 -
Gatifloxacin
Catalog No. A10419 DNA gyrase/topoisomerase IV 抑制剂Gatifloxacin是一种氟喹诺酮类抗生素,可抑制细菌dna回旋酶(IC50 = 0.109 ng/ml)和拓扑异构酶iv(IC50 = 13.8 ng/ml)。 了解更多 -
Ofloxacin (DL8280)
Catalog No. A10666 -
Ametantrone
Catalog No. A12569 topoisomerase II 抑制剂Ametantrone (AM)是一种合成的9,10-蒽二酮,在位置1和4上带有两个(羟乙基氨基)乙基氨基残基,以及其他蒽醌和蒽环类化合物。 了解更多 -
TAS 103 2HCl
Catalog No. A14141 -
Nemorubicin
Catalog No. A14363 Topoisomerase II 抑制剂Nemorubicin是一种抗癌药物,IC50值为0.08 uM。它对抗烷化剂,拓扑异构酶II抑制剂和铂衍生物具有抗性的肿瘤具有活性。它主要通过抑制拓扑异构酶I起作用。 了解更多 -
Voreloxin Hydrochloride
Catalog No. A15280 -
Levofloxacin hydrate
Catalog No. A16167 topoisomerase II IV 抑制剂Levofloxacin hydrate是广谱的第三代氟喹诺酮类抗生素,是具有抗菌活性的氧氟沙星的旋光性L-异构体。 了解更多 -
Clinafloxacin
Catalog No. A16458 DNA gyrase and topoisomerase IV 抑制剂Clinafloxacin是一种氟喹诺酮,可双重抑制肺炎链球菌中的DNA促旋酶和拓扑异构酶IV。 了解更多 -
Pixantrone
Catalog No. A13022 -
Topotecan
Catalog No. A16815 -
MAC glucuronide α-hydroxy lactone-linked SN-38
Catalog No. A18407 Topoisomerase I inhibitorMAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. 了解更多 -
Top1 inhibitor 1
Catalog No. A13304 human topoisomerase I (Top1) inhibitorTop1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM. 了解更多 -
Intoplicine
Catalog No. A20104 DNA topoisomerase I/II inhibitorIntoplicine is a DNA topoisomerase I and II inhibitor. 了解更多 -
Zoliflodacin
Catalog No. A22032 DNA gyrase/topoisomerase inhibitorZoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. 了解更多 -
Dexrazoxane
Catalog No. A17714 topoisomerase IIα inhibitorDexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. 了解更多 -
Costunolide
Catalog No. A10240 -
BEZ235 (NVP-BEZ235, Dactolisib)
Catalog No. A10133 PI3K/mTOR 抑制剂BEZ235 (NVP-BEZ235,Dactolisib)是通过与这些酶的ATP结合裂隙结合来抑制PI3K和mTOR激酶活性。 了解更多 -
KU-60019
Catalog No. A10507 -
VE-821
Catalog No. A11605 -
AZD6738 (Ceralasertib)
Catalog No. A15794 ATR 抑制剂AZD6738是一种有效的ATR激酶抑制剂,对分离的酶的IC50为1 nM,对细胞中ATR激酶依赖性CHK1磷酸化的IC50为74 nM。 了解更多 -
AZD0156
Catalog No. A16419