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DNA Damage

DNA Damage

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Saccharin 1-methylimidazole

Catalog No. A16114
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DNA and RNA synthesis activator

Saccharin 1-methylimidazole被认为是DNA和RNA合成的通用活化剂。了解更多

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SRT1720 HCl

Catalog No. A10862
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SIRT1 Activator

SRT1720 HCl是一种抑制剂，旨在作为瑟土因亚型SIRT1的小分子活化剂。了解更多

Product Citations (7)

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- Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
- Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
- Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
- Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
- Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
- Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
- Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615
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SRT 1720

Catalog No. A15247
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SIRT1 Activator

SRT 1720是人类SIRT1（EC1.5 = 0.16μM）相对于最接近的瑟土因同系物SIRT2和SIRT3（SIRT2：EC1.5 = 37 uM；SIRT3：EC1.5> 300 uM）的选择性激活剂。了解更多

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SRT2104 (GSK2245840)

Catalog No. A14188
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SIRT1 activator

SRT2104 (GSK2245840)是一种选择性sirt1激活剂，参与能量稳态的调节。了解更多

Product Citations (2)

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- Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
- Liu X, .et al. Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats, Life Sci, 2019, Nov 9:117041 PMID: 31715188
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Tenovin-6

Catalog No. A12305
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p53 activator

Tenovin-6是tenovin-1的类似物。Tenovin-6在体外抑制纯化的人SIRT1、SIRT2和SIRT3的蛋白脱乙酰酶活性，IC50值分别为21、10和67 uM。了解更多

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- Igase M,, .et al. Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines, Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684
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UBCS039

Catalog No. A18961
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SIRT6 activator

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. 了解更多

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CAY10602

Catalog No. A19395
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SIRT1 activator

CAY10602 is a SIRT1 activator. 了解更多

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SRT 2183

Catalog No. A12150
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Sirtuin-1 (SIRT1) activator

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. 了解更多

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SRT 1460

Catalog No. A19026
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SIRT1 activator

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. 了解更多

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MDL-800

Catalog No. A17228
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SIRT6 allosteric activator

MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. 了解更多

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SRT 1720 Hydrochloride

Catalog No. A21143
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SIRT1 activator of

SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3. 了解更多

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