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Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.14 mL | 80.68 mL | 161.37 mL |
| 0.5 mM | 3.23 mL | 16.14 mL | 32.27 mL |
| 1 mM | 1.61 mL | 8.07 mL | 16.14 mL |
| 5 mM | 0.32 mL | 1.61 mL | 3.23 mL |
*The above data is based on the productmolecular weight 619.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20986 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 619.71 |
| Formula | C30H29N5O6S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1186222-89-8 |
| Synonyms | 4SC-202, 4SC202, 4SC 202 |
| SMILES | O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2.O=S(C5=CC=C(C)C=C5)(O)=O |
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