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Donepezil是一种非竞争性乙酰胆碱酯酶抑制剂，可以很容易地穿过血脑屏障并增加皮质乙酰胆碱的浓度。众所周知，多奈哌齐是研究阿尔茨海默病的有用工具。
| In vitro | DMSO | 68 mg/mL (179.18 mM) | |
| Ethanol | <1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.35 mL | 131.75 mL | 263.5 mL |
| 0.5 mM | 5.27 mL | 26.35 mL | 52.7 mL |
| 1 mM | 2.64 mL | 13.18 mL | 26.35 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
*The above data is based on the productmolecular weight 379.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13079 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 379.5 |
| Formula | C24H29NO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 120014-06-4 |
| SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC |
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