Dynamin

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Dynamin
A12726	Dynasore	**
A14316	Mdivi-1	***
A15915	Dyngo-4a	****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Dynasore

Catalog No. A12726
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Dynamin 抑制剂

dynasore是一种非竞争性的dynamin 1，dynamin 2和线粒体dynamin（Drp1）GTPase活性抑制剂。了解更多

Product Citations (4)

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- KOLAC UK, .et al. Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells, Research Square, 2022, 03 Jun
- Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKε-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
- Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845
- Naoko Fujii, .et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 PMID: 27733684
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Mdivi-1

Catalog No. A14316
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DRP1 抑制剂

Mdivi-1是线粒体分裂DRP1（与动力蛋白相关的GTPase）和线粒体分裂动力蛋白I（Dnm1）的选择性细胞渗透性抑制剂，IC50为1-10 uM。了解更多

Product Citations (1)

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- KOLAC UK, .et al. Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells, Research Square, 2022, 03 Jun
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Dynamin inhibitory peptide

Catalog No. A14867
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Dynamin 抑制剂

Dynamin inhibitory peptide是GTPase动力蛋白的肽抑制剂。了解更多

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Dyngo-4a

Catalog No. A15915
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Dynamin inhibitor

Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 uM, 1.1uM, and 2.3 uM for DynI (brain), DynI (rec), and DynII (rec), respectively. 了解更多

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