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EAI045是一种有效的选择性EGFR抑制剂。EAI045靶向选定的耐药性EGFR突变体，但保留了野生型受体。
靶点信息
| EGFR mutants | ||||
| In vitro | DMSO | 75 mg/mL (195.61 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.08 mL | 130.41 mL | 260.82 mL |
| 0.5 mM | 5.22 mL | 26.08 mL | 52.16 mL |
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
*The above data is based on the productmolecular weight 383.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16193 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 383.4 |
| Formula | C19H14FN3O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1942114-09-1 |
| Synonyms | EAI-045, EAI 045 |
| SMILES | FC1=CC=C(C(C(N2CC(C=CC=C3)=C3C2=O)C(NC4=NC=CS4)=O)=C1)O |
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