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Hypoxia-inducible factor-1 (HIF-1)是一种转录因子，可控制参与糖酵解，血管生成，迁移和侵袭的基因。棘霉素是HIF-1介导的基因转录的细胞可渗透抑制剂
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.08 mL | 45.4 mL | 90.8 mL |
| 0.5 mM | 1.82 mL | 9.08 mL | 18.16 mL |
| 1 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.82 mL |
*The above data is based on the productmolecular weight 1101.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14021 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1101.3 |
| Formula | C51H64N12O12S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 512-64-1 |
| Synonyms | Antibiotic A 654I, NSC 526417, Quinomycin A, SK 302B, NSC 13502 |
| SMILES | CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OC[C@H](C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)[C@@H](COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C |
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