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EGFR inhibitor是一种可透过细胞的4,6-二取代嘧啶化合物，可选择性抑制EGFR激酶，在体外的IC50值为21 nM，可阻断细胞中的受体自身磷酸化。
| In vitro | DMSO | 79 mg/mL (191.09 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | 2 mg/mL (4.83 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.19 mL | 120.95 mL | 241.9 mL |
| 0.5 mM | 4.84 mL | 24.19 mL | 48.38 mL |
| 1 mM | 2.42 mL | 12.09 mL | 24.19 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
*The above data is based on the productmolecular weight 413.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13673 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 413.4 |
| Formula | C21H18F3N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 879127-07-8 |
| Synonyms | Epidermal Growth Factor Receptor Inhibitor |
| SMILES | C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F |
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