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七叶皂苷E（EE）对局部缺血性心脏具有抗炎和保护作用，EE的有益作用可能为缓解睡眠剥夺引起的行为改变提供有效而有力的策略，并可能通过增加身体耐力来影响免疫增强 和免疫细胞活化。 EE显着降低CIA小鼠的炎性细胞浸润，血管pan形成，软骨损伤，骨侵蚀，TNF-α和IL-6的产生以及通过CYP2C9和CYP2E1代谢的药物的代谢。
| In vitro | DMSO | 93 mg/mL (125.22 mM) | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.46 mL | 67.32 mL | 134.64 mL |
| 0.5 mM | 2.69 mL | 13.46 mL | 26.93 mL |
| 1 mM | 1.35 mL | 6.73 mL | 13.46 mL |
| 5 mM | 0.27 mL | 1.35 mL | 2.69 mL |
*The above data is based on the productmolecular weight 742.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12042 |
|---|---|
| M. Wt | 742.72 |
| Formula | C34H46O18 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 39432-56-9 |
| SMILES | COC1=CC(=CC(=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)OC)C3C4COC(C4CO3)C5=CC(=C(C(=C5)OC)O[C@@H]6[C@H]([C@@H]([C@H]([C@@H](O6)CO)O)O)O)OC |
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