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Endocrinology / Hormones

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SR1078

Catalog No. A15245
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ROR 激动剂

SR1078是视黄酸受体相关的孤儿受体（ROR）RORα/γ的激动剂；增加RORα靶基因的转录；认为可以增加p53的稳定性。了解更多

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SR3335

Catalog No. A15246
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RORα 激动剂

SR3335是一种选择性RORα合成配体，直接与RORα结合，但不与其他ROR结合，并且在基于细胞的测定中用作RORα的选择性部分反向激动剂。了解更多

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SR1001

Catalog No. A13193
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ROR 激动剂

SR1001是选择性的ROR-α和ROR-γ反向激动剂；抑制TH17细胞分化并抑制自身免疫。了解更多

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SR-2211

Catalog No. A13568
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RORr 激动剂

SR-2211选择性结合RORr（Ki = 105 nM），充当体外本构RORr活性的反向激动剂（IC50 = 320 nM）。了解更多

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Cintirorgon (LYC-55716)

Catalog No. A16863
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RORγ 激动剂

Cintirorgon (LYC-55716)是新型口服RAR相关孤儿受体γ（RORγ）激动剂。了解更多

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AZD-0284

Catalog No. A18766
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RORγ 激动剂

AZD-0284 is a potent, selective, inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis. 了解更多

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XY101

Catalog No. A18437
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RORγ inverse 激动剂

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM. 了解更多

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A-9758

Catalog No. A19078
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RORγt inverse 激动剂

A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. 了解更多

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ROR agonist-1

Catalog No. A18569
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ROR 激动剂

ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5. 了解更多

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