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￥ 0.00 Epigenetics
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Ruxolitinib sulfate
Catalog No. A11467 JAK1/2 inhibitorRuxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. 了解更多 -
Oclacitinib maleate
Catalog No. A16640 JAK inhibitorOclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM). 了解更多 -
NVP-BSK805 dihydrochloride
Catalog No. A21406 JAK2 inhibitorNVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively. 了解更多 -
PF-06700841 P-Tosylate
Catalog No. A21652 dual JAK1/TYK2 inhibitorPF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. 了解更多 -
Momelotinib Mesylate
Catalog No. A21658 JAK1/JAK2 inhibitorMomelotinib Mesylate (CYT387 Mesylate) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, appr 10-fold selectivity versus JAK3. 了解更多 -
SGI-1776 (free base)
Catalog No. A10838 PIM1 抑制剂SGI-1776 (free base)是Pim1的一种新型ATP竞争性抑制剂，在无细胞试验中的IC50为7 nM，选择性是Pim2和Pim3的50倍和10倍，对Flt3和haspin也有效。阶段1。 了解更多 -
(Z)-SMI-4a
Catalog No. A11945 Pim 抑制剂SIM-4a是一种Pim激酶抑制剂，可通过激活AMPK来阻断mTORC1的活性。 通常对Pim-2有效，不会显着抑制任何其他丝氨酸/苏氨酸或酪氨酸激酶。 了解更多 -
TCS PIM-1 4a (SMI-4a)
Catalog No. A11967 Pim 抑制剂TCS PIM-1 4a (SMI-4a)是一种具有选择性和ATP竞争性的Pim激酶抑制剂（Pim-1和Pim-2的IC50值分别为24和100 nM）。 了解更多 -
CX-6258 HCl
Catalog No. A14275 Pan-PIM kinase 抑制剂CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂，对Pim1，Pim2和Pim3的IC50为5 nM，25 nM和16 nM。 了解更多 -
LGB-321 HCl
Catalog No. A14420 Pan-PIM kinase 抑制剂LGB-321 HCl是一种有效且选择性的PIM激酶竞争性小分子抑制剂（Pan-PIM激酶抑制剂）。 了解更多 -
CX-6258 hydrochloride hydrate
Catalog No. A15055 Pim 抑制剂CX-6258 hydrochloride hydrate是一种有效的，口服有效的Pim 1/2/3激酶（IC50 = 5 nM/25 nM/16 nM）抑制剂，具有出色的生化效能和激酶选择性。 了解更多 -
PIM-1 Inhibitor 2
Catalog No. A15368 -
TCS PIM-1 1
Catalog No. A15369 Pim-1 Kinase 抑制剂TCS PIM-1 1是一种有效的且具有选择性的ATP竞争性Pim-1 kianse抑制剂，IC50为50 nM，对Pim-2和MEK1/MEK2表现出良好的选择性（IC50s> 20,000 nM）。 了解更多 -
PIM447 (LGH447)
Catalog No. A16807 Pim 抑制剂PIM447 (LGH447)是一种新型的pan-PIM激酶抑制剂，其PIM1，PIM2，PIM3的Ki值分别为6 pM，18 pM，9 pM。它也抑制GSK3β，PKN1和PKCτ，但效力显着降低，IC50在1-5μM之间（相对于PIM上Ki的差异> 105倍）。 了解更多 -
AZD1208 HCl
Catalog No. A16927 -
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SMI-16a
Catalog No. A17157 -
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INCB053914 phosphate
Catalog No. A21444 Pim inhibitorINCB053914 phosphate is an inhibitor of Pim extracted from patent WO 2017044730 A1, compound 1; has an IC50 of less than 35 nM. 了解更多 -
MLN8237 (Alisertib)
Catalog No. A10004 Aurora A Kinase 抑制剂MLN8237 (Alisertib)是一种选择性Aurora A抑制剂，在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。 了解更多 -
Hesperadin
Catalog No. A10448 Aurora B Kinase 抑制剂Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。 了解更多 -
AZD1152-HQPA (Barasertib)
Catalog No. A10109 Aurora Kinase B 抑制剂AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂，Ki值分别为0.36（Aurora B）和1369 nM（Aurora A），与一组其他50种激酶相比具有很高的特异性。 了解更多 -
VX-680 (MK-0457, Tozasertib)
Catalog No. A10981 Aurora Kinase 抑制剂VX-680 (MK-0457,Tozasertib)是一种有效的选择性Aurora激酶小分子抑制剂。 了解更多 -
Danusertib (PHA-739358)
Catalog No. A10715 Aurora 抑制剂Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力 对Lck，VEGFR2/3，c-Kit，CDK2等有效。 了解更多 -
JNJ-7706621
Catalog No. A10494 CDK/Aurora A/B 抑制剂JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂，IC50为9 nM/4 nM，并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B，对Plk1和Wee1没有活性。 了解更多 -
TC-S 7010 (Aurora A Inhibitor I)
Catalog No. A10100 Aurora A 抑制剂TC-S 7010 (Aurora A Inhibitor I)是Aurora A激酶（AurA）的有效和选择性抑制剂，IC50值为3.4 nM（Aurora A），对Aurora B具有极高的选择性1000倍； 用于研究Aurora A激酶的细胞作用的有用工具化合物。 了解更多 -
GSK1070916
Catalog No. A11168 Aurora Kinase B/C 抑制剂GSK1070916是一种有效的Aurora B/C激酶抑制剂（IC50为3.5 nM/6.5 nM），在组织培养细胞和人肿瘤异种移植模型中具有广泛的抗肿瘤活性。 了解更多 -
PF-03814735
Catalog No. A11171 Aurora A/B Kinase 抑制剂PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。 了解更多 -
PHA-680632
Catalog No. A10714 Aurora 抑制剂PHA-680632是Aurora A，Aurora B和Aurora C的有效抑制剂，IC50分别为27 nM，135 nM和120 nM。对于FGFR1，FLT3，LCK，PLK1，STLK2和VEGFR2/3，它的IC50高10到200倍。 了解更多 -
MK-5108 (VX-689)
Catalog No. A11410 Aurora A Kinase 抑制剂MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。 了解更多 -
CYC116 (CYC-116)
Catalog No. A10248 Aurora Kinase 抑制剂CYC116 (CYC-116)是一种有效的Aurora A/B抑制剂，Ki为8.0 nM/9.2 nM，对VEGFR2(Ki为44 nM)作用稍弱。 了解更多 -
MK-8745
Catalog No. A13396
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