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Epigenetics

产品 251 到 300 共 474个

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  1. BI-847325
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    BI-847325

    Catalog No. A15762
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    MEK/Aurora 抑制剂
    BI-847325是一种生物利用型选择性MEK/Aurora双重激酶抑制剂，对于非洲爪蟾Aurora B，人Aurora A和Aurora C以及IC50分别为3 nM，25 nM，15 nM，25 nM和4 nM IC50人MEK1和MEK2。 了解更多
  2. XL-228
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    XL-228

    Catalog No. A13069
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    IGF-1R, Aurora, FGFR, ABL, SRC 抑制剂
    XL228是靶向IGF1R，AURORA激酶，FGFR1-3，ABL和SRC家族激酶的蛋白激酶抑制剂。XL228是一种Aurora A抑制剂（IC50，f3 nmol/L），对ABL1（Ki，5 nmol/L）以及BCR-ABL1 T315I（Ki，1.4 nmol/L）激酶显示出有效的生化活性。 了解更多
  3. TC-A-2317 HCl
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    TC-A-2317 HCl

    Catalog No. A13567
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    Aurora kinase A 抑制剂
    TC-A-2317 HCl是一种有效的Aurora激酶A抑制剂（Ki = 1.2 nM，而抑制Aurora激酶B则为101 nM）。选择性超过60种其他激酶（IC50值> 1000 nM）。表现出良好的细胞通透性和抗肿瘤活性。 了解更多
  4. SCH-1473759
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    SCH-1473759

    Catalog No. A14059
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    Aurora A/B 抑制剂
    SCH-1473759是一种新型的亚纳摩尔Aurora A/B抑制剂，IC50分别为4 nM和13 nM。 了解更多
  5. HOI-07
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    HOI-07

    Catalog No. A15970
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    Aurora B 抑制剂
    HOI-07是有效的Aurora B激酶抑制剂。 了解更多
  6. LY3295668
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    LY3295668

    Catalog No. A16869
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    Aurora A 抑制剂
    LY3295668，也称为AK-01，是有效的Aurora-A激酶抑制剂。 了解更多
  7. AAPK-25
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    AAPK-25

    Catalog No. A19085
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    Aurora/PLK dual 抑制剂
    AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. 了解更多
  8. CCT241736
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    CCT241736

    Catalog No. A21097
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    dual FLT3/Aurora kinase inhibitor
    CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor. 了解更多
  9. SCH-1473759 hydrochloride
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    SCH-1473759 hydrochloride

    Catalog No. A21711
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    Aurora inhibitor
    SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively. 了解更多
  10. EX 527 (Selisistat)
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    EX 527 (Selisistat)

    Catalog No. A10377
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    SIRT1 抑制剂
    EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。 了解更多
  11. AK-7
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    AK-7

    Catalog No. A12904
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    SIRT2 抑制剂
    AK-7是SIRT2的细胞和脑渗透抑制剂（IC50 = 15.5 μM）。 了解更多
  12. Inauhzin
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    Inauhzin

    Catalog No. A12527
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    SIRT1 抑制剂
    Inauhzin是一种有效的SirT1/IMPDH2 的双重抑制剂，可通过抑制SIRT1活性有效地重新激活p53，促进人类癌细胞的p53依赖性凋亡，而不会引起明显的遗传毒性应激。 了解更多
  13. AGK2
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    AGK2

    Catalog No. A14225
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    SIRT2 抑制剂
    AGK2是一种有效的选择性SIRT2抑制剂，IC50为3.5μM。 了解更多
  14. AK-1
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    AK-1

    Catalog No. A14370
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    SIRT2 抑制剂
    AK-1比SIRT1和SIRT3选择性抑制SIRT2。 了解更多
  15. SirReal2
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    SirReal2

    Catalog No. A15902
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    Selective SIRT2 抑制剂
    SirReal2是一种有效的、同型选择性Sirt2抑制剂，IC50为140 nM。 了解更多
  16. Sirtinol
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    Sirtinol

    Catalog No. A12226
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    sirtuin 抑制剂
    Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。 了解更多
  17. OSS-128167
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    OSS-128167

    Catalog No. A17048
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    SIRT 6 抑制剂
    OSS-128167，也称为SIRT6-IN-1，是一种有效的选择性SIRT 6抑制剂，IC50值为89 μM。 了解更多
  18. Thiomyristoyl
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    Thiomyristoyl

    Catalog No. A17166
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    SIRT2 抑制剂
    Thiomyristoyl是一种有效的特异性SIRT2抑制剂，IC50为28 nM。 了解更多
  19. 3-TYP
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    3-TYP

    Catalog No. A17144
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    SIRT3 抑制剂
    3-TYP是SIRT3抑制剂。 了解更多
  20. Cambinol
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    Cambinol

    Catalog No. A12381
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    SIRT1 and SIRT2 inhibitor
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. 了解更多
  21. Salermide
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    Salermide

    Catalog No. A12263
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    Sirt1/Sirt2 inhibitor
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. 了解更多
  22. SIRT-IN-2
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    SIRT-IN-2

    Catalog No. A20961
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    SIRT1/2/3 inhibitor
    SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. 了解更多
  23. SIRT-IN-1
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    SIRT-IN-1

    Catalog No. A20962
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    SIRT1/2/3 inhibitor
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. 了解更多
  24. GSK 1210151A (I-BET151)
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    GSK 1210151A (I-BET151)

    Catalog No. A11783
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    BET Bromodomain 抑制剂
    GSK 1210151A (I-BET151)是溴结构域和额外末端（BET）家族蛋白BRD2，BRD3和BRD4的新型选择性抑制剂。 了解更多
  25. PFI-1
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    PFI-1

    Catalog No. A12545
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    BET 抑制剂
    PFI-1是BET溴结构域抑制剂，对BRD2和BRD4表现出抑制活性。 了解更多
  26. GSK 525762A (I-BET-762)
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    GSK 525762A (I-BET-762)

    Catalog No. A11440
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    BET 抑制剂
    GSK 525762A (I-BET-762)是BET(溴域和末端外)家族的小分子抑制剂。 了解更多
  27. CPI-203
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    CPI-203

    Catalog No. A13068
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    BET bromodomain 抑制剂
    CPI203是溴结构域和额外末端（BET）家族蛋白BRD4的新型有效，选择性和细胞渗透性抑制剂，IC50为?37 nM（BRD4α筛选试验）。 了解更多
  28. Bromosporine
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    Bromosporine

    Catalog No. A13163
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    bromodomain 抑制剂
    Bromosporine是一种针对溴结构域的广谱抑制剂，对于BRD2，BRD4，BRD9和CECR2的IC50分别为0.41μM，0.29μM，0.122μM和0.017μM。 了解更多
  29. UNC 669
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    UNC 669

    Catalog No. A13717
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    L3MBTL 抑制剂
    UNC669是L3MBTL1和L3MBTL3的抑制剂,对L3MBTL1和L3MBTL3具有选择性（IC50分别为4.2μM和3.1μM）。 了解更多
  30. (+)-JQ1
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    (+)-JQ1

    Catalog No. A12729
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    BET 抑制剂
    (+)-JQ1是有效的，高亲和力的选择性BET溴结构域抑制剂。 了解更多
  31. SGC-CBP30
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    SGC-CBP30

    Catalog No. A13227
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    CBP/p300 bromodomain 抑制剂
    SGC-CBP30是一种有效且选择性的CREBBP（CBP）和EP300抑制剂，无细胞试验中IC50分别为21 nM和38 nM。它们是一般的转录共激活因子。 了解更多
  32. OTX015
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    OTX015

    Catalog No. A13890
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    BET 抑制剂
    OTX015是口服可生物利用的BRD2，BRD3和BRD4的小分子抑制剂（EC50s = 10-19 nM）。 了解更多
  33. UNC1215
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    UNC1215

    Catalog No. A12948
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    L3MBTL3 抑制剂
    UNC1215是具有细胞活性的L3MBTL3的强效选择性拮抗剂。 了解更多
  34. I-CBP112
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    I-CBP112

    Catalog No. A13165
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    CBP/p300 bromodomain 抑制剂
    I-CBP112是一种高效且选择性的p300/CBP溴结构域抑制剂（对于CBP，IC50为?0.14-0.17 uM，对于p300为?0.625 uM）。 了解更多
  35. MS436
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    MS436

    Catalog No. A13749
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    BRD4 抑制剂
    MS436是用于BRD4溴结构域的重氮基小分子抑制剂，Ki值为30-50 nM。 了解更多
  36. I-BRD9
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    I-BRD9

    Catalog No. A15872
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    Selective BRD9 抑制剂
    I-BRD9是一种有效的选择性BRD9抑制剂，pIC50为7.3，而对BRD4的pIC50为5.3。 了解更多
  37. BI-7273
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    BI-7273

    Catalog No. A16068
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    BRD9 BD 抑制剂
    BI-7273是一种选择性的，细胞可渗透的BRD9 BD抑制剂。 了解更多
  38. BI-9564
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    BI-9564

    Catalog No. A16196
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    BRD7/9 抑制剂
    BI-9564是BRD9和BRD7溴结构域的有效和选择性抑制剂（Kds分别为14.1和239 nM；IC50分别为75 nM和3.4 uM）。 了解更多
  39. (E)-ZL0420
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    (E)-ZL0420

    Catalog No. A20136
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    BRD4 inhibitor
    ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2. 了解更多
  40. ZL0454
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    ZL0454

    Catalog No. A20123
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    BRD4 inhibitor
    ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2. 了解更多
  41. BMS-986158
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    BMS-986158

    Catalog No. A19442
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    Bromodomain inhibitor
    BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins. 了解更多
  42. MS417
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    MS417

    Catalog No. A19433
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    BRD4 inhibitor
    MS417 is a BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). 了解更多
  43. CD235
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    CD235

    Catalog No. A19115
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    BET bromodomain inhibitor
    CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor. 了解更多
  44. BETd-246
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    BETd-246

    Catalog No. A18913
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    BRD inhibitor
    BETd-246 is a second-generation BET bromodomain (BRD) inhibitor, exhibiting superior selectivity, potency and antitumor activity. 了解更多
  45. Bromodomain IN-1
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    Bromodomain IN-1

    Catalog No. A18845
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    Bromodomain inhibitor
    Bromodomain IN-1 is a Bromodomain inhibitor extracted from patent WO2016069578A1, compound 4 . 了解更多
  46. BRD4 Inhibitor-10
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    BRD4 Inhibitor-10

    Catalog No. A18679
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    BRD4-BD1 inhibitor
    BRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM. 了解更多
  47. GSK9311
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    GSK9311

    Catalog No. A12453
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    inhibitor of the BRPF bromodomain
    GSK9311 is a potent inhibitor of the BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. 了解更多
  48. BET-IN-1
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    BET-IN-1

    Catalog No. A12141
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    bromodomain inhibitor
    BET-IN-1 is a bromodomain inhibitor extracted from patent WO/2013024104A1, compound example 2, has a plC50 in the range 6.0 - 7.0. IC50 value: 6.0 - 7.0 (plC50) Target: bromodomain 了解更多
  49. GS-626510
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    GS-626510

    Catalog No. A13305
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    BET family bromodomains inhibitor
    GS-626510 is a potent, and orally bioavailable BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively. 了解更多
  50. (Rac)-BAY1238097
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    (Rac)-BAY1238097

    Catalog No. A21598
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    BET inhibitor
    (Rac)-BAY1238097 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research. 了解更多

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