Epigenetics
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UNC 2400
Catalog No. A13282 -
EI1
Catalog No. A12711 -
AZ505 ditrifluoroacetate
Catalog No. A13169 SMYD2 抑制剂AZ505 ditrifluoroacetate是一种有效且高度选择性的致癌蛋白SMYD2抑制剂(IC50 = 0.12 uM),具有潜在的抗癌活性,是SMYD3的> 600倍(IC50> 83.3 uM)。DOT1L(IC50> 83.3 uM);EZH2(IC50> 83.3 uM)。 了解更多 -
CPI-1205
Catalog No. A16357 -
EPZ031686
Catalog No. A16375 -
JQEZ5
Catalog No. A16961 -
PF-06726304
Catalog No. A16937 -
JNJ-64619178
Catalog No. A16861 Histone Methyltransferase 抑制剂JNJ-64619178是PRMT5抑制剂,在不同的体外和细胞条件下均具有高选择性和强效性(亚纳摩尔范围,PRMT5-MEP-50 IC50 = 0.14 nM),并具有良好的药代动力学和安全性。 了解更多 -
BIX-01338 hydrate
Catalog No. A21812 histone lysine methyltransferase inhibitorBIX-01338 hydrate is a histone lysine methyltransferase inhibitor. 了解更多 -
Amodiaquine dihydrochloride dihydrate
Catalog No. A16405 Amodiaquine dihydrochloride dihydrate是人红细胞中组胺N-甲基转移酶的有效,非竞争性抑制剂,也用作抗疟疾和抗炎药。 了解更多 -
C7280948
Catalog No. A13876 -
MS023
Catalog No. A12585 -
HLCL-61
Catalog No. A15870 -
GSK-3326595 (EPZ015938)
Catalog No. A16862 PRMT5 抑制剂GSK-3326595 (EPZ015938)是一种有效的,选择性的,可逆的蛋白精氨酸甲基转移酶5(PRMT5)抑制剂,IC50为6.2 nM。 了解更多 -
PF-06855800
Catalog No. A16860 PRMT5 抑制剂PF-06855800 (PF06855800)是一种有效的,选择性的,SAM竞争性,BBB渗透性,口服活性的蛋白精氨酸甲基转移酶PRMT5抑制剂,Ki为0.02 nM。 了解更多 -
FK-506 (Tacrolimus)
Catalog No. A10389 mTOR 抑制剂FK-506 (Tacrolimus)是一种免疫抑制药物,通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物,从而降低T细胞中肽酰脯氨酰异构酶活性。 了解更多 -
Ascomycin
Catalog No. A12592 -
Calcineurin Autoinhibitory Peptide
Catalog No. A15376 Calcineurin Autoinhibitory Peptide是Ca2+钙调蛋白依赖性蛋白磷酸酶(钙调神经磷酸酶)(IC50?10 uM)的选择性抑制剂。不抑制PP1,PP2A或CaM激酶II(IC50> 100 mM)。 了解更多 -
INCA-6
Catalog No. A15380 -
Ascomycin (FK520)
Catalog No. A15788 Calcineurin/PP2B 抑制剂Ascomycin (FK520)是他克莫司的乙基类似物(FK506),具有强的免疫抑制特性。已经研究出其用于治疗自身免疫疾病和皮肤疾病,并防止器官移植后的排斥反应。 了解更多 -
Cyclosporine
Catalog No. A15434 -
DPM-1001
Catalog No. A18674 PTP1B inhibitorDPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property. 了解更多 -
PTP1B-IN-8
Catalog No. A19109 PTP1B inhibitorPTP1B-IN-8 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1. 了解更多 -
PTP1B-IN-3
Catalog No. A21149 PTP1B inhibitorPTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively. 了解更多 -
PTP1B-IN-1
Catalog No. A22000 PTP1B inhibitorPTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis. 了解更多 -
TCS 401 free base
Catalog No. A15390 PTP1B 抑制剂TCS 401是蛋白酪氨酸磷酸酶1B(PTP1B)的选择性抑制剂(对于PTP1B,CD45 D1D2,PTPβ,PTPεD1,SHP-1,Ki值为0.29、59、560、1100,> 2000,> 2000和> 2000μM,分别为PTPαD1和LAR D1D2)。 了解更多