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Epigenetics

产品 301 到 350 共 545个

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  1. Sirtinol
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    Sirtinol

    Catalog No. A12226
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    sirtuin 抑制剂
    Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。 了解更多
  2. Fisetin (Fustel)
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    Fisetin (Fustel)

    Catalog No. A10388
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    Fisetin (Fustel)是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。 了解更多
  3. OSS-128167
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    OSS-128167

    Catalog No. A17048
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    SIRT 6 抑制剂
    OSS-128167，也称为SIRT6-IN-1，是一种有效的选择性SIRT 6抑制剂，IC50值为89 μM。 了解更多
  4. Thiomyristoyl
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    Thiomyristoyl

    Catalog No. A17166
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    SIRT2 抑制剂
    Thiomyristoyl是一种有效的特异性SIRT2抑制剂，IC50为28 nM。 了解更多
  5. 3-TYP
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    3-TYP

    Catalog No. A17144
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    SIRT3 抑制剂
    3-TYP是SIRT3抑制剂。 了解更多
  6. MDL-800
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    • 最新产品

    MDL-800

    Catalog No. A17228
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    SIRT6 allosteric activator
    MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. 了解更多
  7. CAY10602
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    CAY10602

    Catalog No. A19395
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    SIRT1 activator
    CAY10602 is a SIRT1 activator. 了解更多
  8. SRT 1460
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    SRT 1460

    Catalog No. A19026
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    SIRT1 activator
    SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. 了解更多
  9. UBCS039
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    UBCS039

    Catalog No. A18961
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    SIRT6 activator
    UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. 了解更多
  10. SRT 2183
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    SRT 2183

    Catalog No. A12150
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    Sirtuin-1 (SIRT1) activator
    SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. 了解更多
  11. Cambinol
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    Cambinol

    Catalog No. A12381
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    SIRT1 and SIRT2 inhibitor
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. 了解更多
  12. Salermide
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    Salermide

    Catalog No. A12263
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    Sirt1/Sirt2 inhibitor
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. 了解更多
  13. PROTAC Sirt2 Degrader-1
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    PROTAC Sirt2 Degrader-1

    Catalog No. A20005
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    Sirt2 degrader
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. 了解更多
  14. SRT 1720 Hydrochloride
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    SRT 1720 Hydrochloride

    Catalog No. A21143
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    SIRT1 activator of
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3. 了解更多
  15. SIRT-IN-2
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    SIRT-IN-2

    Catalog No. A20961
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    SIRT1/2/3 inhibitor
    SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. 了解更多
  16. SIRT-IN-1
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    SIRT-IN-1

    Catalog No. A20962
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    SIRT1/2/3 inhibitor
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. 了解更多
  17. Sirt2-IN-1
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    Sirt2-IN-1

    Catalog No. A19348
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    Sirt2 inhibitor
    Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM. 了解更多
  18. JFD00244
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    JFD00244

    Catalog No. A19517
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    SIRT2 inhibitor
    JFD00244 is a sirtuin 2 (SIRT2) inhibitor. Anti-tumor effect. 了解更多
  19. SIRT5 inhibitor 1
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    SIRT5 inhibitor 1

    Catalog No. A19841
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    SIRT5 inhibitor
    SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. 了解更多
  20. SirReal1-O-propargyl
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    SirReal1-O-propargyl

    Catalog No. A20091
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    Sirt2 inhibitor
    SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. 了解更多
  21. GSK 1210151A (I-BET151)
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    GSK 1210151A (I-BET151)

    Catalog No. A11783
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    BET Bromodomain 抑制剂
    GSK 1210151A (I-BET151)是溴结构域和额外末端（BET）家族蛋白BRD2，BRD3和BRD4的新型选择性抑制剂。 了解更多
  22. PFI-1
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    PFI-1

    Catalog No. A12545
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    BET 抑制剂
    PFI-1是BET溴结构域抑制剂，对BRD2和BRD4表现出抑制活性。 了解更多
  23. GSK 525762A (I-BET-762)
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    GSK 525762A (I-BET-762)

    Catalog No. A11440
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    BET 抑制剂
    GSK 525762A (I-BET-762)是BET(溴域和末端外)家族的小分子抑制剂。 了解更多
  24. CPI-203
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    CPI-203

    Catalog No. A13068
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    BET bromodomain 抑制剂
    CPI203是溴结构域和额外末端（BET）家族蛋白BRD4的新型有效，选择性和细胞渗透性抑制剂，IC50为?37 nM（BRD4α筛选试验）。 了解更多
  25. Bromosporine
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    Bromosporine

    Catalog No. A13163
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    bromodomain 抑制剂
    Bromosporine是一种针对溴结构域的广谱抑制剂，对于BRD2，BRD4，BRD9和CECR2的IC50分别为0.41μM，0.29μM，0.122μM和0.017μM。 了解更多
  26. UNC 669
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    UNC 669

    Catalog No. A13717
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    L3MBTL 抑制剂
    UNC669是L3MBTL1和L3MBTL3的抑制剂,对L3MBTL1和L3MBTL3具有选择性（IC50分别为4.2μM和3.1μM）。 了解更多
  27. (+)-JQ1
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    (+)-JQ1

    Catalog No. A12729
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    BET 抑制剂
    (+)-JQ1是有效的，高亲和力的选择性BET溴结构域抑制剂。 了解更多
  28. SGC-CBP30
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    SGC-CBP30

    Catalog No. A13227
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    CBP/p300 bromodomain 抑制剂
    SGC-CBP30是一种有效且选择性的CREBBP（CBP）和EP300抑制剂，无细胞试验中IC50分别为21 nM和38 nM。它们是一般的转录共激活因子。 了解更多
  29. OTX015
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    OTX015

    Catalog No. A13890
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    BET 抑制剂
    OTX015是口服可生物利用的BRD2，BRD3和BRD4的小分子抑制剂（EC50s = 10-19 nM）。 了解更多
  30. UNC1215
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    UNC1215

    Catalog No. A12948
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    L3MBTL3 抑制剂
    UNC1215是具有细胞活性的L3MBTL3的强效选择性拮抗剂。 了解更多
  31. I-CBP112
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    I-CBP112

    Catalog No. A13165
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    CBP/p300 bromodomain 抑制剂
    I-CBP112是一种高效且选择性的p300/CBP溴结构域抑制剂（对于CBP，IC50为?0.14-0.17 uM，对于p300为?0.625 uM）。 了解更多
  32. MS436
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    MS436

    Catalog No. A13749
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    BRD4 抑制剂
    MS436是用于BRD4溴结构域的重氮基小分子抑制剂，Ki值为30-50 nM。 了解更多
  33. I-BRD9
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    I-BRD9

    Catalog No. A15872
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    Selective BRD9 抑制剂
    I-BRD9是一种有效的选择性BRD9抑制剂，pIC50为7.3，而对BRD4的pIC50为5.3。 了解更多
  34. BI-7273
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    BI-7273

    Catalog No. A16068
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    BRD9 BD 抑制剂
    BI-7273是一种选择性的，细胞可渗透的BRD9 BD抑制剂。 了解更多
  35. BI-9564
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    BI-9564

    Catalog No. A16196
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    BRD7/9 抑制剂
    BI-9564是BRD9和BRD7溴结构域的有效和选择性抑制剂（Kds分别为14.1和239 nM；IC50分别为75 nM和3.4 uM）。 了解更多
  36. VZ185
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    VZ185

    Catalog No. A18685
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    dual BRD7/9 PROTAC degrader
    VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively. 了解更多
  37. ZXH-3-26
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    ZXH-3-26

    Catalog No. A18399
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    PROTAC BRD4 degrader
    ZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM. 了解更多
  38. (E)-ZL0420
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    (E)-ZL0420

    Catalog No. A20136
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    BRD4 inhibitor
    ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2. 了解更多
  39. ZL0454
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    ZL0454

    Catalog No. A20123
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    BRD4 inhibitor
    ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2. 了解更多
  40. BMS-986158
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    BMS-986158

    Catalog No. A19442
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    Bromodomain inhibitor
    BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins. 了解更多
  41. MS417
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    MS417

    Catalog No. A19433
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    BRD4 inhibitor
    MS417 is a BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). 了解更多
  42. MZP-54
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    MZP-54

    Catalog No. A19426
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    BRD3/4 degrader
    MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. 了解更多
  43. MZP-55
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    MZP-55

    Catalog No. A19415
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    BRD3/4 degrader
    MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. 了解更多
  44. dBET57
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    dBET57

    Catalog No. A19133
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    BRD4BD1degrader
    dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. 了解更多
  45. CD235
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    CD235

    Catalog No. A19115
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    BET bromodomain inhibitor
    CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor. 了解更多
  46. BETd-246
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    BETd-246

    Catalog No. A18913
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    BRD inhibitor
    BETd-246 is a second-generation BET bromodomain (BRD) inhibitor, exhibiting superior selectivity, potency and antitumor activity. 了解更多
  47. Bromodomain IN-1
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    Bromodomain IN-1

    Catalog No. A18845
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    Bromodomain inhibitor
    Bromodomain IN-1 is a Bromodomain inhibitor extracted from patent WO2016069578A1, compound 4 . 了解更多
  48. BRD4 Inhibitor-10
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    BRD4 Inhibitor-10

    Catalog No. A18679
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    BRD4-BD1 inhibitor
    BRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM. 了解更多
  49. GSK9311
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    GSK9311

    Catalog No. A12453
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    inhibitor of the BRPF bromodomain
    GSK9311 is a potent inhibitor of the BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. 了解更多
  50. BET-IN-1
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    BET-IN-1

    Catalog No. A12141
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    bromodomain inhibitor
    BET-IN-1 is a bromodomain inhibitor extracted from patent WO/2013024104A1, compound example 2, has a plC50 in the range 6.0 - 7.0. IC50 value: 6.0 - 7.0 (plC50) Target: bromodomain 了解更多

产品 301 到 350 共 545个

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