EPZ-6438 (Tazemetostat)

Name: EPZ-6438 (Tazemetostat)
SKU: A12712

目录号: A12712

EZH2 抑制剂

Product Citations (3)

EPZ-6438 (Tazemetostat) Chemical Structure

CAS NO. 1403254-99-8

EPZ-6438 (Tazemetostat)是一种有效的，选择性的，口服可利用的EZH2酶促活性小分子抑制剂，无细胞试验中Ki 和 IC50分别为2.5 nM 和 11 nM。它诱导SMARCB1缺失的MRT细胞中的凋亡和分化。

库存：现货

规格	价格	数量
5 mg	￥ 350.00
10 mg	￥ 490.00
25 mg	￥ 630.00
50 mg	￥ 770.00
10mM * 1mL in DMSO	￥ 420.00

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产品详情

生物活性

靶点信息

EZH2 (Cell-free assay)	EZH2 (Cell-free assay)
2.5 nM(Ki)	2.5 nM(Ki)

溶解度 *

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (6.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.46 mL	87.3 mL	174.6 mL
0.5 mM	3.49 mL	17.46 mL	34.92 mL
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

*The above data is based on the productmolecular weight 572.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12712
作用机制	Inhibitor (抑制剂)
M. Wt	572.74
Formula	C34H44N4O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1403254-99-8
Synonyms	EPZ6438, EPZ 6438
SMILES	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5