Estrogen Receptors

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GSK4716

Catalog No. A16956
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ERRβ & ERRγ 激动剂

GSK4716是与雌激素相关的受体ERRβ/γ激动剂，对ERRα，ERα和ERβ具有最小的活性。了解更多

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- Sen He, .et al. The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors, Toxicology, 2021, May 4;457:152805 PMID: 33961950
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(R)-Equol

Catalog No. A16986
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Estrogen receptor 激动剂

(R)-Equol是ER＆alpha和ER＆beta的激动剂，Kis分别为27.4和15.4 nM。了解更多

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- Gao X, .et al. Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol, Toxins (Basel), 2020, Jan 26;12(2) PMID: 31991913
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PROTAC ERRα ligand 2

Catalog No. A18939
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ERRα inverse agonist

PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多

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MK-6913

Catalog No. A12311
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Estrogen receptor β agonist

Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist. 了解更多

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TAK-875 (Fasiglifam)

Catalog No. A11018
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GPR 激动剂

TAK-875 (Fasiglifam)是一种有效的，选择性的GPR40激动剂。了解更多

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- Ying Liu, .et al. A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice, Nucleic Acids Res, 2018, Oct 12; 46(18): 9864-9874 PMID: 30219861
- Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
- Hodaka Yamada, .et al. Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells, Sci Rep, 2016, 6: 25912 PMID: 27180622
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Kaempferol

Catalog No. A10495
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ERRα and ERRγ inverse 激动剂

Kaempferol被发现抑制Ki为0.3-0.5 μM的牛主动脉肌球蛋白轻链激酶，并且还被发现通过新的ERK-NFκB-cMyc-p21途径抑制VEGF表达和体外血管生成。了解更多

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Hexestrol

Catalog No. A10451
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Estrogen/progestogen Receptor 激动剂

Hexestrol是一种致癌的合成雌激素，可抑制微管聚合和带状结构的形成。它是脂质过氧化的抑制剂。了解更多

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GSK1292263

Catalog No. A10439
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GPR119 激动剂

GSK-1292263是一种新型GPR119激动剂。了解更多

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- Inoue A, .et al. Illuminating G-Protein-Coupling Selectivity of GPCRs, Cell, 2019, Jun 13;177(7):1933-1947 PMID: 31160049
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LY500307

Catalog No. A10550
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ERβ 激动剂

LY500307是一种强效选择性雌激素受体β激动剂，EC50为0.66 nM。了解更多

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DY131

Catalog No. A15071
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ERRβ and ERRγ 激动剂

DY131 (GSK 9089)是一种新型的ERRα和ERRβ的选择性激动剂。了解更多

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