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Evacetrapib (LY2484595)

Evacetrapib (LY2484595)

Name: Evacetrapib (LY2484595)
SKU: A11397

目录号: A11397

CETP 抑制剂

Evacetrapib (LY2484595) Chemical Structure

CAS NO. 1186486-62-3

Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂，IC50为5.5 nM，可在不增加醛固酮或血压的情况下升高HDL胆固醇。

库存：现货

规格	价格	数量
5 mg	￥ 1,050.00
10 mg	￥ 1,680.00
25 mg	￥ 3,500.00
50 mg	￥ 5,250.00
10mM * 1mL in DMSO	￥ 1,477.00

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生物活性

Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂，IC50为5.5 nM，可在不增加醛固酮或血压的情况下升高HDL胆固醇。

靶点信息

CETP
5.5 nM

溶解度 *

In vitro (25°C)	DMSO	11 mg/mL (17.22 mM)
	Water	Insoluble
	Ethanol	11 mg/mL (17.22 mM)
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.66 mL	78.29 mL	156.58 mL
0.5 mM	3.13 mL	15.66 mL	31.32 mL
1 mM	1.57 mL	7.83 mL	15.66 mL
5 mM	0.31 mL	1.57 mL	3.13 mL

*The above data is based on the productmolecular weight 638.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11397
作用机制	Inhibitor (抑制剂)
M. Wt	638.65
Formula	C31H36F6N6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1186486-62-3
Synonyms	LY2484595, LY-2484595, LY 2484595
SMILES	CC1=CC(=C2C(=C1)[C@H](CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C