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FG-2216是一种有效的HIF-脯氨酰羟化酶抑制剂，对PDH2酶的IC50为3.9 uM；生物利用度并在体内诱导显着且可逆的Epo诱导。
靶点信息
| PHD2 | ||||
| 3.9 μM |
| In vitro (25°C) | DMSO | 48 mg/mL (171.02 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+40% PEG 300+2% Twenn 80+ddH2O | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.63 mL | 178.15 mL | 356.3 mL |
| 0.5 mM | 7.13 mL | 35.63 mL | 71.26 mL |
| 1 mM | 3.56 mL | 17.82 mL | 35.63 mL |
| 5 mM | 0.71 mL | 3.56 mL | 7.13 mL |
*The above data is based on the productmolecular weight 280.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15530 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 280.66 |
| Formula | C12H9ClN2O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 223387-75-5 |
| Synonyms | YM-311 |
| SMILES | C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O |
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