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Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys.
| In vitro | DMSO | 97 mg/mL (193.36 mM) | |
| Ethanol | 23 mg/mL (45.85 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.93 mL | 99.67 mL | 199.34 mL |
| 0.5 mM | 3.99 mL | 19.93 mL | 39.87 mL |
| 1 mM | 1.99 mL | 9.97 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
*The above data is based on the productmolecular weight 501.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17477 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 501.65 |
| Formula | C27H31N7OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 247257-48-3 |
| Synonyms | BR-A657; BR A657; BRA657; BRA 657; Fimasartan. brand name: Kanarb. |
| SMILES | S=C(N(C)C)CC1=C(C)N=C(CCCC)N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C1=O |
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