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Flumazenil是竞争性抑制GABA/苯二氮卓受体复合物上苯二氮卓识别位点的活性。Flumazenil在一些活性动物模型中是弱部分激动剂，但在人类中很少或没有激动剂活性。
靶点信息
| GABAA receptor | ||||
| In vitro | DMSO | 4 mg/mL (13.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.97 mL | 164.85 mL | 329.71 mL |
| 0.5 mM | 6.59 mL | 32.97 mL | 65.94 mL |
| 1 mM | 3.3 mL | 16.49 mL | 32.97 mL |
| 5 mM | 0.66 mL | 3.3 mL | 6.59 mL |
*The above data is based on the productmolecular weight 303.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10397 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 303.3 |
| Formula | C15H14FN3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 78755-81-4 |
| Synonyms | Ro 15-1788 |
| SMILES | CCOC(=O)c1ncn2c1CN(C)C(=O)c1c2ccc(c1)F |
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