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FMK是p90核糖体蛋白S6激酶RSK1和RSK2的有效，高度特异性和不可逆的抑制剂。Fmk结合在CTKD ATP结合位点，并抑制Ser386处的RSK自磷酸化。Fmk诱导人类表达FGFR3的t（4; 14）阳性多发性骨髓瘤细胞发生明显凋亡。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.21 mL | 146.04 mL | 292.08 mL |
| 0.5 mM | 5.84 mL | 29.21 mL | 58.42 mL |
| 1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
*The above data is based on the productmolecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11423 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 342.37 |
| Formula | C18H19FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 821794-92-7 |
| SMILES | CC1=CC=C(C=C1)C2=C(N(C3=C2C(=NC=N3)N)CCCO)C(=O)CF |
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