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Forskolin是具有抗高血压，正性肌力和腺苷酸环化酶激活特性的细胞渗透性二萜。Forskolin 是一种有效的 腺苷酸环化酶 激活剂，结合到 I 型腺苷酸环化酶 IC50 为 41 nM，激活 I 型腺苷酸环化酶 EC50 为 0.5 μM。
靶点信息
| Adenylyl cyclase (AC) (A wide variety of cell types) | ||||
| In vitro | DMSO | 72 mg/mL (175.39 mM) | |
| Water | Insoluble | ||
| Ethanol | 33 mg/mL (80.39 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.36 mL | 121.8 mL | 243.6 mL |
| 0.5 mM | 4.87 mL | 24.36 mL | 48.72 mL |
| 1 mM | 2.44 mL | 12.18 mL | 24.36 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
*The above data is based on the productmolecular weight 410.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12917 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 410.51 |
| Formula | C22H34O7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 66575-29-9 |
| Synonyms | Coleonol, Colforsin |
| SMILES | CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O |
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