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Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.65 mL | 68.26 mL | 136.52 mL |
| 0.5 mM | 2.73 mL | 13.65 mL | 27.3 mL |
| 1 mM | 1.37 mL | 6.83 mL | 13.65 mL |
| 5 mM | 0.27 mL | 1.37 mL | 2.73 mL |
*The above data is based on the productmolecular weight 732.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21873 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 732.51 |
| Formula | C23H24FN6Na2O9P.6H2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 914295-16-2 |
| Synonyms | R788 (disodium hexahydrate), R 788, R-788 |
| SMILES | COC1=CC(NC2=NC=C(C(NC3=NC(N4COP([O-])([O-])=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC.O.[Na+].[Na+].O.O.O.O.O |
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