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Freselestat是一种有效的嗜中性粒细胞弹性蛋白酶抑制剂。 在模拟体外循环过程中，Freselestat减少了炎症介质。 ONO-6818显着降低了白介素8和C5b-9的产量。 在再循环期间，ONO-6818不能调节CD11b和L-选择素的变化。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.1 mL | 110.49 mL | 220.99 mL |
| 0.5 mM | 4.42 mL | 22.1 mL | 44.2 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
*The above data is based on the productmolecular weight 452.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12780 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 452.51 |
| Formula | C23H28N6O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 208848-19-5 |
| Synonyms | ONO6818, ONO 6818 |
| SMILES | C3=C(C1=NC=C(C(N1CC(NC(C(C2=NN=C(O2)C(C)(C)C)=O)C(C)C)=O)=O)N)C=CC=C3 |
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