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FTI-277 HCl是法呢基转移酶（FTase）的抑制剂。一种高效的Ras CAAX拟肽药物，可拮抗H-Ras和K-Ras致癌信号。
靶点信息
| FTase | GGTase I | |||
| 500 pM | 50 nM |
| In vitro | DMSO | 90 mg/mL (185.92 mM) | |
| Water | 16 mg/mL (33.04 mM) | ||
| Ethanol | Warmed: 13 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.66 mL | 103.29 mL | 206.58 mL |
| 0.5 mM | 4.13 mL | 20.66 mL | 41.32 mL |
| 1 mM | 2.07 mL | 10.33 mL | 20.66 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.13 mL |
*The above data is based on the productmolecular weight 484.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14439 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 484.07 |
| Formula | C22H30ClN3O3S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 180977-34-8 |
| Synonyms | FTI 277, FTI277 |
| SMILES | COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.Cl.Cl |
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