FXR

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GW4064

Catalog No. A11141
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FXR 激动剂

GW4064是选择性的非甾体类法尼醇X受体（FXR）激动剂（EC50 = 15 nM）。了解更多

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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Takae K, .et al. Evidence for the involvement of FXR signaling in ovarian granulosa cell function, J Reprod Dev, 2018, Nov 16 PMID: 30449821
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WAY-362450

Catalog No. A11186
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FXR 激动剂

WAY-362450是一种高效，选择性和口服可生物利用的法呢类X受体（FXR）激动剂（EC50：4 nM，eff = 149％）。了解更多

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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Dong-Hyun Kim, .et al. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis, FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930
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Lithocholic acid

Catalog No. A12547
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FXR 激动剂

Lithocholic acid是胆汁酸，用作去污剂以溶解脂肪以供吸收。了解更多

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T0901317

Catalog No. A12652
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LXR/FXR 激动剂

T0901317是有效的，高亲和力的肝X受体（LXR）激动剂（EC50~50 nM，LXR-β和LXR-β的Kd值分别为7和22 nM）。了解更多

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- Tian Yongsong, .et al. Tritium hydrogen-isotope exchange with electron-poor tertiary benzenesulfonamide moiety; application in late-stage labeling of T0901317, J Labelled Comp Radiopharm, 2022, Feb;65(2):36-44 PMID: 34957593
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Obeticholic Acid

Catalog No. A13866
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FXR 激动剂

Obeticholic Acid是一种有效的选择性法呢类X受体（FXR）激动剂，EC50为99 nM。了解更多

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- Tomasz Kostrzewski, .et al. A Microphysiological System for Studying Nonalcoholic Steatohepatitis, Hepatol Commun, 2019, 13 November
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LY2562175

Catalog No. A17016
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FXR 激动剂

LY2562175是体外有效的选择性FXR激动剂，其EC50值为193 nM。具有强大的脂质调节特性，可降低临床前物种中的LDL和甘油三酸酯，同时提高HDL。了解更多

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Px-104

Catalog No. A16999
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FXR 激动剂

Px-104，也称为Px-102，是一种潜在的法呢素X受体（FXR）激动剂，可用于治疗非酒精性脂肪肝。了解更多

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PX20606 trans-isomer

Catalog No. A16997
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FXR 激动剂

PX20606 trans-isomer在小鼠和猴子中诱导高密度脂蛋白介导的跨肝胆固醇外流，并预防胆固醇酯转移蛋白转基因低密度脂蛋白受体(-/-)mice的动脉粥样硬化。了解更多

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Cilofexor

Catalog No. A13143
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FXR agonist

Cilofexor (GS-9674) is a farnesoid X receptor (FXR) agonist. 了解更多

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Nidufexor

Catalog No. A12625
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FXR agonist

Nidufexor is a farnesoid X receptor (FXR) agonist. 了解更多

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INT-767

Catalog No. A21494
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dual FXR/TGR5 agonist

INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. 了解更多

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Fexaramine

Catalog No. A21771
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FXR agonist

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. 了解更多

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