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GANT61是GLI1和GLI2诱导的转录的抑制剂，以5μM的IC50抑制hedgehog，对其他途径（例如TNF和糖皮质激素受体基因反式激活）表现出选择性。
靶点信息
| GLI1 (HEK293T cells expressing GLI1) | ||||
| 5 μM |
| In vitro | DMSO | Insoluble | |
| Water | Insoluble | ||
| Ethanol | 11 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.28 mL | 116.38 mL | 232.77 mL |
| 0.5 mM | 4.66 mL | 23.28 mL | 46.55 mL |
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13252 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 429.61 |
| Formula | C27H35N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 500579-04-4 |
| Synonyms | NSC136476, NSC-136476, GANT 61, GANT-61 |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
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