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GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3的IC50值分别为5、18和8 nM。
靶点信息
| Akt1 (Cell-free assay) | Akt3 (Cell-free assay) | Akt2 (Cell-free assay) | ||
| 5 nM | 8 nM | 18 nM |
| In vitro | DMSO | 91 mg/mL (198.69 mM) | |
| Water | Insoluble | ||
| Ethanol | 91 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.83 mL | 109.17 mL | 218.34 mL |
| 0.5 mM | 4.37 mL | 21.83 mL | 43.67 mL |
| 1 mM | 2.18 mL | 10.92 mL | 21.83 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
*The above data is based on the productmolecular weight 458. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11246 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 458 |
| Formula | C24H32ClN5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1001264-89-6 |
| Synonyms | GDC0068, RG7440 |
| SMILES | C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O |
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