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GDC-0810 (Brilanestrant)是一种口服可生物利用的选择性雌激素受体降解剂（SERD），在耐他莫昔芬的乳腺癌异种移植物中表现出强大的活性。
| In vitro | DMSO | 82 mg/mL (183.48 mM) | |
| Water | Insoluble | ||
| Ethanol | 82 mg/mL (183.48 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.38 mL | 111.88 mL | 223.76 mL |
| 0.5 mM | 4.48 mL | 22.38 mL | 44.75 mL |
| 1 mM | 2.24 mL | 11.19 mL | 22.38 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
*The above data is based on the productmolecular weight 446.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15958 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 446.91 |
| Formula | C26H20ClFN2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1365888-06-7 |
| Synonyms | RG6046, ARN-810, ARN810, ARN 810 |
| SMILES | O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F |
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