微信关注
China
Total item
Cart Subtotal
￥ 0.00 产品详情
GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂，IC50为4.2 nM，对MEK1的选择性选择性是对MEK2的100倍以上，并且当针对一组超过100个丝氨酸的抑制剂进行测试时，没有显示出明显的抑制作用。
靶点信息
| MEK1 | ||||
| 4.2 nM |
| In vitro (25°C) | DMSO | 88 mg/mL (165.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 41 mg/mL (77.17 mM) | ||
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.86 mL | 94.32 mL | 188.64 mL |
| 0.5 mM | 3.77 mL | 18.86 mL | 37.73 mL |
| 1 mM | 1.89 mL | 9.43 mL | 18.86 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11441 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 530.1 |
| Formula | C21H21F3IN3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 934660-93-2 |
| Synonyms | XL518, XL 518, XL-518, RG7420 |
| SMILES | C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O |
产品资料
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
GSK1120212 (JTP-74057, Trametinib)
GSK1120212 (JTP-74057,Trametinib)强烈阻止了MEK1和MEK2激酶的活性，而不是其他98种激酶的活性。
RO5126766 (CH5126766)
RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶（MAPK）具有特异性的蛋白激酶抑制剂，具有潜在的抗肿…
Ulixertinib (BVD-523, VRT752271)
Ulixertinib (BVD-523,VRT752271)是ERK蛋白激酶的吡咯抑制剂。
MEK inhibitor
MEK inhibitor是一种有效的MEK抑制剂，抗肿瘤剂。
U0126-EtOH
U0126-EtOH是MEK1和MEK2的抑制剂，IC50分别为72 nM和58 nM。
Arctigenin
Arctigenin是抗氧化剂，消炎药，抗增殖药和抗病毒药。它通过抑制IκBα磷酸化和p65核移位来抑制LPS诱导的iNOS…
Cobimetinib (racemate)
Cobimetinib (racemate)是一种有效的，高度选择性的MEK1/2抑制剂。
Keywords:购买 GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) 供应商 | 订购 GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) 价格 | GDC-0973 (Cobimetinib) 生产商 | 订单 GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) 代理商 | 购买 934660-93-2| 934660-93-2 供应商 | 订购 934660-93-2 | 934660-93-2 价格 | 934660-93-2 生产商 | 订单 934660-93-2 | 934660-93-2 代理商|buy GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) Supplier | purchase GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) cost | GDC-0973 (Cobimetinib) manufacturer | order GDC-0973 (Cobimetinib) | GDC-0973 (Cobimetinib) distributor | buy 934660-93-2| 934660-93-2 Supplier | purchase 934660-93-2 | 934660-93-2 cost | 934660-93-2 manufacturer | order 934660-93-2 | 934660-93-2 distributor
联系我们
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: sales@adooq.com
Not your Region? View all Distributors
ADOOQ 产品质量保证
We promise all products to perform as described.