GKT137831

Name: GKT137831
SKU: A14433

目录号: A14433

NOX1/4 抑制剂

Product Citations (1)

GKT137831 Chemical Structure

CAS NO. 1218942-37-0

GKT137831是针对NOX1和NOX4酶的一流抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 630.00
10 mg	￥ 980.00
25 mg	￥ 2,240.00
10mM * 1mL in DMSO	￥ 700.00

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生物活性

GKT137831是针对NOX1和NOX4酶的一流抑制剂。

靶点信息

NOX1	NOX4
110 nM(Ki)	140 nM(Ki)

溶解度 *

In vitro (25°C)	DMSO	Warmed: 72 mg/mL (182.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+2% Tween 80+30% PEG 300+ddH2O	8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.33 mL	126.63 mL	253.26 mL
0.5 mM	5.07 mL	25.33 mL	50.65 mL
1 mM	2.53 mL	12.66 mL	25.33 mL
5 mM	0.51 mL	2.53 mL	5.07 mL

*The above data is based on the productmolecular weight 394.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14433
作用机制	Inhibitor (抑制剂)
M. Wt	394.85
Formula	C21H19ClN4O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1218942-37-0
Synonyms	GKT-137831, GKT 137831
SMILES	CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl