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GNE 2861 is a PAK inhibitor that displays group II selectivity. GNE 2861 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.6 mL | 123.01 mL | 246.01 mL |
| 0.5 mM | 4.92 mL | 24.6 mL | 49.2 mL |
| 1 mM | 2.46 mL | 12.3 mL | 24.6 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
*The above data is based on the productmolecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21697 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 406.48 |
| Formula | C22H26N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1394121-05-1 |
| Synonyms | GNE2861, GNE-2861 |
| SMILES | OC1(C#CC2=CC=C3N=C(NCCOC)N(C4=NC(N)=NC=C4)C3=C2)CCCCC1 |
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