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GSK2193874被确定为选择性的口服活性TRPV4阻滞剂，可通过重组TRPV4通道和天然内皮TRPV4电流抑制Ca(2+)流入。
| In vitro | DMSO | 95 mg/mL (137.35 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 48 mg/mL (69.4 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.46 mL | 72.29 mL | 144.59 mL |
| 0.5 mM | 2.89 mL | 14.46 mL | 28.92 mL |
| 1 mM | 1.45 mL | 7.23 mL | 14.46 mL |
| 5 mM | 0.29 mL | 1.45 mL | 2.89 mL |
*The above data is based on the productmolecular weight 691.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14201 |
|---|---|
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 691.62 |
| Formula | C37H38BrF3N4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1336960-13-4 |
| Synonyms | GSK 2193874, GSK2193874 |
| SMILES | C1CCN(CC1)C2CCN(CC2)CC3=C(N=C4C=C(C=CC4=C3C(=O)NC5(CC5)C6=CC=CC=C6)Br)C7=CC(=CC=C7)C(F)(F)F |
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