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GSK-2250665A是pKi = 9.2的Itk抑制剂，它对Aurora B激酶和Btk（pIC50值分别为6.4和6.5）和一组其他激酶表现出对Itk的选择性。 抑制PBMC中IFNγ的产生。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.76 mL | 108.79 mL | 217.58 mL |
| 0.5 mM | 4.35 mL | 21.76 mL | 43.52 mL |
| 1 mM | 2.18 mL | 10.88 mL | 21.76 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
*The above data is based on the productmolecular weight 459.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17191 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 459.61 |
| Formula | C26H29N5OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1246030-96-5 |
| Synonyms | GSK2250665A, GSK-2250665A |
| SMILES | CCC1=CC=C(N=C(NC3=NC(N[C@H]5CC[C@H](O)CC5)=NC(CC4=CC=CC=C4)=C3)S2)C2=C1 |
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