GSK2656157

Name: GSK2656157
SKU: A13577

目录号: A13577

PERK 抑制剂

Product Citations (2)

GSK2656157 Chemical Structure

CAS NO. 1337532-29-2

GSK2656157是PERK酶活性的ATP竞争性抑制剂，IC50为0.9 nmol/L。对于PER（K）IC50值> 100 nmol/L，对300种激酶组合具有高度选择性。

库存：现货

规格	价格	数量
10 mg	￥ 490.00
25 mg	￥ 1,050.00
50 mg	￥ 1,750.00
100 mg	￥ 2,800.00
10mM * 1mL in DMSO	￥ 525.00

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生物活性

GSK2656157是PERK酶活性的ATP竞争性抑制剂，IC50为0.9 nmol/L。对于PER（K）IC50值> 100 nmol/L，对300种激酶组合具有高度选择性。

靶点信息

PERK (Cell-free assay)
0.9 nM

溶解度 *

In vitro (25°C)	DMSO	28 mg/mL (67.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.01 mL	120.06 mL	240.12 mL
0.5 mM	4.8 mL	24.01 mL	48.02 mL
1 mM	2.4 mL	12.01 mL	24.01 mL
5 mM	0.48 mL	2.4 mL	4.8 mL

*The above data is based on the productmolecular weight 416.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13577
作用机制	Inhibitor (抑制剂)
M. Wt	416.45
Formula	C23H21FN6O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1337532-29-2
Synonyms	GSK 2656157
SMILES	CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C