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GW842166X是一种选择性的非大麻类CB2受体激动剂，EC50为63 nM，对CB1受体没有显著的活性。
靶点信息
| CB2 | ||||
| 63 nM(EC50) |
| In vitro (25°C) | DMSO | 18 mg/mL (40.06 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.26 mL | 111.3 mL | 222.59 mL |
| 0.5 mM | 4.45 mL | 22.26 mL | 44.52 mL |
| 1 mM | 2.23 mL | 11.13 mL | 22.26 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
*The above data is based on the productmolecular weight 449.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11253 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 449.25 |
| Formula | C18H17Cl2F3N4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 666260-75-9, 956013-38-0 |
| SMILES | C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C=C(C=C3)Cl)Cl |
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