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HDM201是新型，高效且选择性的p53-Mdm2相互作用抑制剂，其对Mdm2的亲和常数在皮摩尔范围内，相对Mdm4的选择性比大于10000倍。
| In vitro | DMSO | 98 mg/mL (176.44 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (5.4 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18 mL | 90.02 mL | 180.05 mL |
| 0.5 mM | 3.6 mL | 18 mL | 36.01 mL |
| 1 mM | 1.8 mL | 9 mL | 18 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
*The above data is based on the productmolecular weight 555.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16834 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 555.41 |
| Formula | C26H24Cl2N6O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1448867-41-1 |
| Synonyms | NVP-HDM201, HDM 201, HDM-201 |
| SMILES | O=C1N(C2=CC(Cl)=CN(C)C2=O)[C@@H](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C(C)C |
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