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Stem Cells / Wnt /
Hedgehog

Hedgehog

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GDC-0449 (Vismodegib)

Catalog No. A10258
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Hedgehog 拮抗剂

GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。了解更多

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- Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
- Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
- Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536
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Cyclopamine

Catalog No. A10249
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Hedgehog signaling 抑制剂

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路， IC50 为46 nM。了解更多

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LY2940680 (Taladegib)

Catalog No. A11048
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SMO 拮抗剂

LY2940680 (Taladegib)已显示可影响由Hedgehog（Hh）蛋白引发的癌细胞信号通路。了解更多

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TAK-441

Catalog No. A11351
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Hedgehog 抑制剂

TAK-441是吡咯并[3，2-c]吡啶衍生物，作为高效口服活性hedgehog信号抑制剂。了解更多

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SANT-1

Catalog No. A13095
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Sonic hedgehog 抑制剂

SANT-1是有效的细胞渗透性Sonic刺猬（Shh）信号传导抑制剂；平滑活性的高亲和力拮抗剂（KD = 1.2 nM）。以20 nM的IC50抑制平滑的激动剂作用（在Shh-LIGHT2细胞中）。了解更多

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GANT61

Catalog No. A13252
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GLI 拮抗剂

GANT61是GLI1和GLI2诱导的转录的抑制剂，以5μM的IC50抑制hedgehog，对其他途径（例如TNF和糖皮质激素受体基因反式激活）表现出选择性。了解更多

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- Cheng Zhou, .et al. GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia, Cell Death Dis, 2021, Mar 3;12(3):231 PMID: 33658491
- Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170
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GANT 58

Catalog No. A11442
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GLI 拮抗剂

GANT 58是有效的Gli拮抗剂，可抑制GLI1诱导的转录，IC50为5 μM。了解更多

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Hh-Ag1.5

Catalog No. A12920
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Hedgehog 抑制剂

Hh-Ag1.5是Hedgehog途径中最有效，选择性最强的小分子激动剂之一，靶向EC50?1 nM的平滑（Smo）。了解更多

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JK 184

Catalog No. A12925
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Hedgehog 抑制剂

JK 184是有效的下游hedgehog (Hh)信号抑制剂，可防止Gli依赖性转录活性(IC50 = 30 nM)。了解更多

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HhAntag

Catalog No. A12418
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HhAntag是GLI1介导的转录的小分子抑制剂，GLI1介导的转录是Hedgehog（Hh）途径的重要下游元素。了解更多

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MK-4101

Catalog No. A16111
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Hedgehog 抑制剂

MK-4101是Hedgehog通路的有效和选择性抑制剂。了解更多

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RU-SKI 43

Catalog No. A16229
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Hhat 抑制剂

RU-SKI 43是Hhat（刺猬酰基转移酶）的小分子抑制剂，该酶负责将棕榈酸酯附着到Shh上。了解更多

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HPI-4

Catalog No. A16349
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hedgehog 抑制剂

HPI-4是一种刺猬（Hh）信号通路抑制剂，中位抑制浓度（IC50）小于10μM。了解更多

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Purmorphamine

Catalog No. A11480
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Hedgehog signaling activator

Purmorphamine是一种2，6，9-三取代嘌呤，可促进人和小鼠间充质祖细胞向成骨细胞的分化。了解更多

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U18666A

Catalog No. A20195
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cholesterol synthesis/Hedgehog inhibitor

U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. 了解更多

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Mebendazole

Catalog No. A16606
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Hedgehog inhibitor

Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. 了解更多

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