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HLI 373是Hdm2泛素连接酶（E3）的抑制剂，可阻断Hdm2介导的泛素化，p53的蛋白酶体降解并激活p53依赖性转录。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.14 mL | 120.68 mL | 241.36 mL |
| 0.5 mM | 4.83 mL | 24.14 mL | 48.27 mL |
| 1 mM | 2.41 mL | 12.07 mL | 24.14 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
*The above data is based on the productmolecular weight 414.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15347 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 414.32 |
| Formula | C18H23N5O2.2HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 502137-98-6 |
| SMILES | CN1C2=CC=CC=C2C(=C3C1=NC(=O)N(C3=O)C)NCCCN(C)C.Cl.Cl |
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