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Stem Cells / Wnt /
β-catenin

β-catenin

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Longdaysin

Catalog No. A21022
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Wnt/??-catenin signaling inhibitor

Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. 了解更多

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SKL2001

Catalog No. A16707
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Wnt/β-catenin agonist

SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. 了解更多

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HLY78

Catalog No. A18402
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Wnt/β-catenin 激活剂

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. 了解更多

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Wnt/β-catenin agonist 1

Catalog No. A18689
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Wnt/β-catenin 激动剂

Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. 了解更多

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IWP-4

Catalog No. A17004
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Wnt/β-catenin signaling 抑制剂

IWP-4是Wnt /β-catenin信号传导的新型有效抑制剂。了解更多

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iCRT3

Catalog No. A16847
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Wnt/β-catenin 拮抗剂

iCRT3是Wnt /β-catenin信号的拮抗剂，在Wnt反应性STF16-luc报告基因检测中，IC50为8.2 nM。了解更多

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KYA1797K

Catalog No. A16353
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Wnt/beta-catenin 抑制剂

KYA1797K是一种高效且选择性的Wnt/β-catenin抑制剂，IC50为0.75 μM（TOPflash分析）。了解更多

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iCRT 14

Catalog No. A16218
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CRT 抑制剂

iCRT 14是一种新型的有效的β-catenin反应转录（CRT）抑制剂（在Wnt途径活性测定中IC50 = 40.3 nM）。了解更多

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Hexachlorophene

Catalog No. A16217
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Wnt/beta-catenin 抑制剂

Hexachlorophene是一种有效的KCNQ1/KCNE1钾通道激活剂，EC50为4.61±1.29 uM。也是Wnt/β-catenin信号的抑制剂。了解更多

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Cardiogenol C HCl

Catalog No. A16198
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Cardiogenol C HCl是一种二氨基嘧啶化合物，可诱导MHC-（肌球蛋白重链）阳性心肌细胞从胚胎干细胞中分化出来，EC50值为0.1 uM。心源醇C上调心脏标志物并诱导沿袭定型祖细胞的心脏功能特性。了解更多

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IQ-1

Catalog No. A16064
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Wnt/beta-catenin 抑制剂

IQ-1是可透过细胞的四氢异喹啉亚基化合物，可调节Wnt/β-catenin信号传导。了解更多

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PRI-724

Catalog No. A15856
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CBP/beta-catenin 拮抗剂

PRI-724是ICG-001的异构体或对映异构体，是一种强力的特异性抑制剂癌症干细胞中的Wnt信号通路具有潜在的抗肿瘤活性。了解更多

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- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
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Cardiogenol C hydrochloride

Catalog No. A15773
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Cardiogenol C hydrochloride是心肌细胞中胚胎干细胞分化的有效且可渗透细胞的诱导剂，显示Ec50为100nm。了解更多

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BC2059

Catalog No. A14381
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beta-catenin inhibitor

BC2059 is an orally bioavailable and potent beta-catenin inhibitor. 了解更多

Product Citations (1)

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- Ji-Hye Jung, .et al. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities, Stem Cells Dev, 2016, Jul 1; 25(13): 1006-1019 PMID: 27188501
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WAY-316606

Catalog No. A13986
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sFRP-1 抑制剂

WAY-316606是分泌蛋白sFRP-1的小分子抑制剂，sFRP-1是分泌糖蛋白Wnt的内源性拮抗剂。了解更多

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FH535

Catalog No. A13795
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β-Catenin/Tcf 抑制剂

FH535是Wnt/β-catenin和PPAR的抑制剂，具有抗肿瘤活性。了解更多

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- Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.
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IWR-1-endo

Catalog No. A12737
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Wnt 抑制剂

IWR-1-endo是Wnt应答的有效抑制剂，可阻断基于细胞的Wnt /β-catenin途径报道分子应答，IC50值为180 nM。 Wnt蛋白与细胞表面的受体结合，启动信号级联反应，从而导致β-catenin激活基因转录。了解更多

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- Charles A.Herring, .et al. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution, Cell, 2022, Oct 27;S0092-8674(22)01258-2 PMID: 36318921
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ICG-001

Catalog No. A11039
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Wnt/beta-catenin 抑制剂

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。了解更多

Product Citations (5)

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- Seonmin Choi, .et al. Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors, Yonsei Med J, 2021, Nov;62(11):1042-1051 PMID: 34672138
- Jasper C.Munro, .et al. Cardiac function and feed efficiency: increased right-heart workload in feed inefficient beef cattle, Livest Sci, 2019, 229 (2019) 159-169
- Kim JH, .et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus, Cell Rep, 2019, May 14;27(7):2105-2118.e5 PMID: 31091449
- Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
- Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536

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