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IDF 11774是一种低氧诱导因子-1（HIF-1）抑制剂。它降低了HIFα-1的HRE荧光素酶活性；（IC50＝3.65 μM），并阻断HIF116结肠癌细胞缺氧下的HIFα-1的积累。
| In vitro | DMSO | 13 mg/mL (35.27 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (10.85 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.14 mL | 135.68 mL | 271.36 mL |
| 0.5 mM | 5.43 mL | 27.14 mL | 54.27 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16845 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 368.51 |
| Formula | C23H32N2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1429054-28-3 |
| Synonyms | IDF11774, IDF 11774 |
| SMILES | O=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2 |
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