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Immunology & Inflammation

Immunology & Inflammation

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Diphenyleneiodonium chloride

Catalog No. A13359
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GPR3 激动剂/NOS/ NADPH oxidases 抑制剂

Diphenyleneiodonium是一种有效的不可逆的巨噬细胞抑制剂NOS2（iNOS）和内皮细胞NOS3（eNOS）抑制剂。了解更多

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ATI-2341

Catalog No. A16351
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CXCR4 激动剂

ATI-2341是针对C-X-C趋化因子受体4型（CXCR4）（EC50 = 194 nM）的pepducin，是一种变构激动剂，可激活抑制性异三聚体G蛋白（Gi），从而促进cAMP生成的抑制并诱导钙动员。了解更多

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Kynurenic acid

Catalog No. A16581
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GPR35/CXCR8 拮抗剂

Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. 了解更多

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PS372424

Catalog No. A19421
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Human CXCR3 拮抗剂

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM. 了解更多

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GPR35 agonist 1

Catalog No. A12462
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GPR35/CXCR8 agonist

GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. 了解更多

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Kynurenic acid sodium

Catalog No. A20000
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GPR35/CXCR8 agonist

Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. 了解更多

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VTX-2337

Catalog No. A12841
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TLR8 激动剂

VTX-2337是一种具有潜在的免疫刺激和抗肿瘤活性的小分子Toll样受体8（TLR8）激动剂。了解更多

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- Yinwen Cheng, .et al. The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent, Sci Rep, 2021, Jan 15;11(1):1535 PMID: 33452311
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Gardiquimod TFA

Catalog No. A17050
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TLR7 激动剂

Gardiquimod TFA是一种化合物，可选择性作用于小鼠和人类形式的Toll样受体7（TLR7）。它起免疫反应调节剂的作用。CAS：1020412-43-4（游离碱）了解更多

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TLR7-agonist-1

Catalog No. A17018
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TLR7 激动剂

TLR7-agonist-1是一种有效且选择性的Toll样受体7（TLR7）激动剂，LEC为0.4 μM。了解更多

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Imiquimod (Aldara)

Catalog No. A10469
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TLR7 激动剂

Imiquimod (Aldara)是一种杂环咪唑并喹啉酰胺，用作免疫反应调节剂。了解更多

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- David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
- Kunishita Y, .et al. TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis, Front Immunol, 2020, Feb 7;11:98 PMID: 32117252
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GS-9620

Catalog No. A13251
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TLR7 激动剂

GS-9620是Toll样受体7的有效选择性口服活性小分子激动剂。了解更多

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- Yu-Geun Ji, .et al. Determination of motolimod concentration in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study, J Pharm Biomed Anal, 2019, 12 November, 112987
- Zhikuan Zhang, .et al. Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands, Cell Reports, 2018, 25(12): 3371-3381.e5 PMID: 30566863
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Isatoribine

Catalog No. A14351
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TLR7 激动剂

Isatoribine是一种新型的鸟苷类似物，在体内和体外均显示出免疫刺激活性。了解更多

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Resiquimod

Catalog No. A15890
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TLR7/8 激动剂

Resiquimod是一种免疫应答调节剂，可作为有效的TLR 7/8激动剂。阶段2。了解更多

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PF-4878691

Catalog No. A12233
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TLR7 agonist

PF-4878691 (3M-852A) is a potent, orally active, and selective Toll-like receptor 7 (TLR7) agonist modelled to dissociate its antiviral and inflammatory activities. 了解更多

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TLR7/8 agonist 1 dihydrochloride

Catalog No. A21700
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TLR7/8 agonist

TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. 了解更多

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NSC5844

Catalog No. A15924
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CCR1 激动剂

NSC5844是具有C-C趋化因子受体1型（CCR1）激动特性的双喹啉化合物。了解更多

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ZK-756326 dihydrochloride

Catalog No. A16363
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CCR8 激动剂

ZK-756326是有效的，选择性的非肽CCR8趋化因子受体激动剂。ZK 756326抑制了CCR8配体I-309（CCL1）的结合，IC（50）值为1.8μM。了解更多

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LMD-009

Catalog No. A18643
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CCR8 激动剂

LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. 了解更多

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