Immunology & Inflammation
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NOX2 inhibitor
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.
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L-PGDS 抑制剂
AT-56是脂环素型前列腺素D合酶(L-PGDS)的口服活性抑制剂(Ki = 75μM,IC50 = 95μM)。
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HPGDS 抑制剂
HPGDS inhibitor 1是一种新的选择性造血前列腺素d合酶(HPGDS)抑制剂,IC50值为0.7 nM。
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hPGDS 抑制剂
SAR191801是一种hPGDS抑制剂,在荧光偏振分析或EIA分析中,IC50为12 nM。
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H-PGDS 抑制剂
HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM.
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arginase 抑制剂
BEC HCl是一种缓慢结合的竞争性精氨酸酶抑制剂,精氨酸酶II和大鼠精氨酸酶I的Ki分别为0.31 μM(pH7.5)和0.4-0.6 μM。
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Arginase 抑制剂
CB-1158,也称为INCB01158,是一种有效的口服活性精氨酸酶抑制剂,IC50 = 89nM。
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arginase 抑制剂
CB-1158,也称为INCB01158,是一种有效的口服精氨酸酶抑制剂,IC50 = 89 nM。
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Arginase inhibitor
nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia.
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arginases I and II inhibitor
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.
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SIK/TBK-1/IKKe 抑制剂
MRT67307是一种强效双IKK?和TBK1抑制剂,IC50分别为160和19 nM。
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SIK2 inhibitor
ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L.
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SIK inhibitor
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.
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SIK inhibitor
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
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LTA4 hydrolase 抑制剂
SC 57461A是体外有效的重组人白三烯A4水解酶抑制剂(Askonas等,2002)。
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