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Immunology & Inflammation

产品 151 到 200 共 214个

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  1. SCH 546738
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    SCH 546738

    Catalog No. A21554
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    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. 了解更多
  2. AMG 487 S-enantiomer
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    AMG 487 S-enantiomer

    Catalog No. A21874
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    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. 了解更多
  3. NBI-74330
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    NBI-74330

    Catalog No. A21158
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    CXCR3 antagonist
    NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. 了解更多
  4. Dihydromyricetin (Ampeloptin)
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    Dihydromyricetin (Ampeloptin)

    Catalog No. A10252
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    Dihydropyrimidinase 抑制剂
    Dihydromyricetin (Ampeloptin)是具有良好性能的天然抗氧化剂。 了解更多
  5. Acetylcysteine
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    Acetylcysteine

    Catalog No. A10032
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    Acetylcysteine是一种是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可处理扑热息痛(对乙酰氨基酚)过量。 了解更多
  6. Febuxostat (TEI-6720)
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    Febuxostat (TEI-6720)

    Catalog No. A10382
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    xanthine oxidase 抑制剂
    Febuxostat (TEI-6720)是黄嘌呤氧化酶的非嘌呤抑制剂（Ki = 1.2 nM）。 了解更多
  7. Allopurinol sodium
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    Allopurinol sodium

    Catalog No. A10056
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    xanthine oxidase inhibitor
    Allopurinol sodium是次黄嘌呤（体内天然存在的嘌呤）的结构异构体，是黄嘌呤氧化酶的抑制剂。 了解更多
  8. Allopurinol
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    Allopurinol

    Catalog No. A10055
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    Allopurinol是嘌呤类似物；它是次黄嘌呤（人体中天然存在的嘌呤）的结构异构体，是黄嘌呤氧化酶的抑制剂。 了解更多
  9. 6-Benzylaminopurine
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    6-Benzylaminopurine

    Catalog No. A13053
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    6-Benzylaminopurine是第一代合成细胞分裂素，可调节植物抗氧化防御系统的活性，其处理诱导植物生长发育。 了解更多
  10. Asymmetric dimethylarginine
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    Asymmetric dimethylarginine

    Catalog No. A18704
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    NOS inhibitor
    Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. 了解更多
  11. L-NIO dihydrochloride
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    L-NIO dihydrochloride

    Catalog No. A13027
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    NOS inhibitor
    L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. 了解更多
  12. Diphenyleneiodonium chloride
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    Diphenyleneiodonium chloride

    Catalog No. A13359
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    GPR3 激动剂/NOS/ NADPH oxidases 抑制剂
    Diphenyleneiodonium是一种有效的不可逆的巨噬细胞抑制剂NOS2（iNOS）和内皮细胞NOS3（eNOS）抑制剂。 了解更多
  13. 1400W Dihydrochloride
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    1400W Dihydrochloride

    Catalog No. A13583
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    INOS 抑制剂
    1400W Dihydrochloride是一种缓慢，紧密结合，有效和高度选择性的诱导型一氧化氮合酶抑制剂（Kd = 7 nM）。对nNOS和eNOS具有选择性（Ki值分别为2和50μM）。细胞可渗透并在体内具有活性。 了解更多
  14. Biopterin
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    Biopterin

    Catalog No. A13901
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    NOS cofactor
    Biopterin是一氧化氮合酶（NOS）辅助因子四氢-L-生物蝶呤（BH4）的氧化形式。可以通过硫氧还蛋白还原酶，然后是二氢蝶呤还原酶或还原型谷胱甘肽，将L-生物蝶呤还原为BH4。在培养中对人黑素细胞具有极强的毒性（48小时后IC50 = 0.2 uM）。 了解更多
  15. Gw274150
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    Gw274150

    Catalog No. A12710
    iNOS 抑制剂
    GW274150是有效且高度选择性的iNOS抑制剂，可减少实验性肾脏缺血/再灌注损伤。 了解更多
  16. Oltipraz
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    Oltipraz

    Catalog No. A13164
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    Nrf2 activator
    Oltipraz抑制HIF-1alpha活性和HIF-1alpha依赖性肿瘤生长，这可能是由于S6K1抑制结合H2O2清除作用导致HIF-1alpha稳定性降低所致。 了解更多
  17. CDDO-EA
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    CDDO-EA

    Catalog No. A16299
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    Nrf2 activator
    CDDO-EA是Nrf2/ARE的激活剂；神经保护作用。 了解更多
  18. NK-252
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    NK-252

    Catalog No. A16300
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    Nrf2 activator
    NK-252是Nrf2活化剂，与OPZ相比，具有更大的Nrf2活化电位。 了解更多
  19. AKBA
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    AKBA

    Catalog No. A17908
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    Nrf2 activator
    AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. 了解更多
  20. Nrf2-IN-1
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    Nrf2-IN-1

    Catalog No. A12561
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    Nrf2 inhibitor
    Nrf2-IN-1 (Compound 4f) is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), acts as a promising agent in acute myeloid leukemia (AML) therapy. 了解更多
  21. (R)-Sulforaphane
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    (R)-Sulforaphane

    Catalog No. A21690
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    Keap1/Nrf2/ARE pathway inducer
    (R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. 了解更多
  22. RTA-408
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    RTA-408

    Catalog No. A14417
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    Nrf2 抑制剂
    RTA-408是一种合成的三萜类化合物，可有效激活抗氧化转录因子Nrf2并抑制促炎转录因子NF-kB。 了解更多
  23. Brusatol
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    Brusatol

    Catalog No. A16893
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    Nrf2 抑制剂
    Brusatol是一种生化物质，从Brucea javanica植物中分离出来，可抑制Nrf2。 了解更多
  24. ML-385
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    ML-385

    Catalog No. A17172
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    NRF2 抑制剂
    ML-385是核因子红系2相关因子2（Nrf2）的抑制剂，IC50值为1.9μM。 了解更多
  25. Montelukast
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    Montelukast

    Catalog No. A17780
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    LTR antagonist
    Montelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. 了解更多
  26. AS-35
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    AS-35

    Catalog No. A19409
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    LTR antagonist
    AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. 了解更多
  27. Pranlukast (ONO 1078)
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    Pranlukast (ONO 1078)

    Catalog No. A11908
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    Pranlukast (ONO 1078)是一种选择性的半胱氨酰白三烯受体拮抗剂。 了解更多
  28. MK-0679 (Verlukast)
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    MK-0679 (Verlukast)

    Catalog No. A11607
    LTD4 receptor 拮抗剂
    MK-0679 (Verlukast)是有效的白三烯D4拮抗剂。 了解更多
  29. LY 255283
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    LY 255283

    Catalog No. A13090
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    BLT2 receptors 拮抗剂
    LY 255283是一种有效的 BLT2 receptors 拮抗剂。 了解更多
  30. MK-571
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    MK-571

    Catalog No. A12529
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    CysLT1 receptor 拮抗剂
    MK-571是有效的CysLT1（LTD4）白三烯受体反向激动剂，EC50值为1.3 nM。 了解更多
  31. MK-571 sodium salt
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    MK-571 sodium salt

    Catalog No. A15983
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    CysLT1 receptor 拮抗剂
    MK-571 sodium salt是一种选择性的口服活性CysLT1受体拮抗剂。它阻断LTD4而不是LTC4与人和豚鼠肺膜的结合，Ki值分别为0.22 nM和2.1 nM。 了解更多
  32. MLT-748
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    MLT-748

    Catalog No. A18954
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    MALT1 inhibitor
    MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. 了解更多
  33. MLT-747
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    MLT-747

    Catalog No. A18942
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    MALT1 inhibitor
    MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM. 了解更多
  34. MI 2
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    MI 2

    Catalog No. A12928
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    MALT1 抑制剂
    MI 2直接与MALT1结合并在体外和体内抑制活化的B细胞样弥漫性大B细胞淋巴瘤（ABC-DLBCL）。 了解更多
  35. PD1-PDL1 inhibitor 2
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    PD1-PDL1 inhibitor 2

    Catalog No. A15906
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    PD-1/PD-L1 interaction 抑制剂
    PD1-PDL1 inhibitor 2 是PD-1/PD-L1相互作用抑制剂。 了解更多
  36. PD1-PDL1 inhibitor 1
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    PD1-PDL1 inhibitor 1

    Catalog No. A15882
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    PD1-PDL1 inhibitor 1 是PD-1/PD-L1相互作用抑制剂。 了解更多
  37. Apocynin (Acetovanillone)
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    Apocynin (Acetovanillone)

    Catalog No. A11989
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    NADPH-oxidase 抑制剂
    Apocynin (Acetovanillone)是NADPH氧化酶抑制剂。 了解更多
  38. ML 171
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    ML 171

    Catalog No. A13360
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    NOX1 抑制剂
    ML 171是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 了解更多
  39. GKT137831
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    GKT137831

    Catalog No. A14433
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    NOX1/4 抑制剂
    GKT137831是针对NOX1和NOX4酶的一流抑制剂。 了解更多
  40. APX-115
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    APX-115

    Catalog No. A18737
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    Nox inhibitor
    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury. 了解更多
  41. GSK2795039
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    GSK2795039

    Catalog No. A20998
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    NOX2 inhibitor
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis. 了解更多
  42. AT 56
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    AT 56

    Catalog No. A13032
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    L-PGDS 抑制剂
    AT-56是脂环素型前列腺素D合酶（L-PGDS）的口服活性抑制剂（Ki = 75μM，IC50 = 95μM）。 了解更多
  43. HPGDS inhibitor 1
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    HPGDS inhibitor 1

    Catalog No. A12258
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    HPGDS 抑制剂
    HPGDS inhibitor 1是一种新的选择性造血前列腺素d合酶(HPGDS)抑制剂，IC50值为0.7 nM。 了解更多
  44. SAR191801
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    SAR191801

    Catalog No. A14444
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    hPGDS 抑制剂
    SAR191801是一种hPGDS抑制剂，在荧光偏振分析或EIA分析中，IC50为12 nM。 了解更多
  45. HPGDS inhibitor 2
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    HPGDS inhibitor 2

    Catalog No. A18390
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    H-PGDS 抑制剂
    HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM. 了解更多
  46. BEC HCl
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    BEC HCl

    Catalog No. A15881
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    arginase 抑制剂
    BEC HCl是一种缓慢结合的竞争性精氨酸酶抑制剂，精氨酸酶II和大鼠精氨酸酶I的Ki分别为0.31 μM（pH7.5）和0.4-0.6 μM。 了解更多
  47. CB-1158
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    CB-1158

    Catalog No. A16929
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    Arginase 抑制剂
    CB-1158，也称为INCB01158，是一种有效的口服活性精氨酸酶抑制剂，IC50 = 89nM。 了解更多
  48. CB-1158
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    CB-1158

    Catalog No. A16864
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    arginase 抑制剂
    CB-1158，也称为INCB01158，是一种有效的口服精氨酸酶抑制剂，IC50 = 89 nM。 了解更多
  49. nor-NOHA acetate
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    nor-NOHA acetate

    Catalog No. A21673
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    Arginase inhibitor
    nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. 了解更多
  50. Arginase inhibitor 1
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    Arginase inhibitor 1

    Catalog No. A21007
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    arginases I and II inhibitor
    Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. 了解更多

产品 151 到 200 共 214个

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分类
  1. IL Receptor (11)
  2. COX (64)
  3. CCR (29)
  4. Toll-like Receptors (19)
  5. CXCR (30)
  6. ROS (6)
  7. NOS (6)
  8. Keap1-Nrf2 (9)
  9. LTR (7)
  10. MALT (3)
  11. PD-1/PD-L1 (2)
  12. NADPH oxidase (6)
  13. PGE Synthase (4)
  14. Arginase (5)
  15. Salt-inducible Kinase (SIK) (4)
  16. Immunology & Inflammation related (11)
作用机制
  1. Inhibitor (抑制剂) (115)
  2. Agonist (激动剂) (18)
  3. Antagonist (拮抗剂) (50)
  4. Activator (激活剂) (6)
  5. Modulator (调节剂) (3)
靶点
  1. 5-lipoxygenase (1)
  2. COX (13)
  3. COX-1 (13)
  4. COX-2 (23)
  5. CXCL12 (1)
  6. CXCL8 (2)
  7. CXCR1 (4)
  8. CXCR2 (9)
  9. CXCR4 (11)
  10. Histamine H1 receptor (1)
  11. HSP90 (1)
  12. LOX (1)
  13. Src (1)
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