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Immunology & Inflammation

产品 1 到 50 共 214个

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  1. CORM-3
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    CORM-3

    Catalog No. A14285
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    CORM-3是一种具有抗炎和保护心脏功能的水溶性一氧化碳释放分子。 了解更多
  2. 21-Deacetoxy Deflazacort
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    21-Deacetoxy Deflazacort

    Catalog No. A13823
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    21-Deacetoxy Deflazacort是Deflazacort（一种系统性的皮质类固醇）的中间体。 了解更多
  3. Anti-Inflammatory Peptide 1
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    Anti-Inflammatory Peptide 1

    Catalog No. A14874
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    Anti-Inflammatory Peptide 1属于合成寡肽组，对应于子宫珠蛋白和脂皮质激素I之间氨基酸序列相似性高的区域。 了解更多
  4. SC 57461A
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    SC 57461A

    Catalog No. A15312
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    LTA4 hydrolase 抑制剂
    SC 57461A是体外有效的重组人白三烯A4水解酶抑制剂（Askonas等，2002）。 了解更多
  5. Aceneuramic acid hydrate
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    Aceneuramic acid hydrate

    Catalog No. A15585
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    Immunomodulator
    Aceneuramic acid hydrate是潜在地用于治疗遗传性包涵体肌病（HIBM）的免疫调节剂。 了解更多
  6. Eugenol
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    Eugenol

    Catalog No. A15754
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    Eugenol是丁香油和其他植物中发现的天然气味化学物质。丁香酚的生理作用是通过增加组胺释放和细胞介导的免疫力来实现的。 了解更多
  7. Escin
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    Escin

    Catalog No. A16119
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    Escin是皂苷的混合物，具有七叶树七叶树（七叶树）中的抗炎，血管收缩和血管保护作用。 了解更多
  8. Loxoprofen
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    Loxoprofen

    Catalog No. A16139
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    Loxoprofen是一种非甾体类抗炎药。 了解更多
  9. Prostaglandin F2 alpha
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    Prostaglandin F2 alpha

    Catalog No. A16333
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    Prostaglandin F2α是天然存在的前列腺素，用于医学中引产和流产。 了解更多
  10. Benzydamine HCl
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    Benzydamine HCl

    Catalog No. A14562
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    Benzydamine HCl是一种具有局部麻醉和镇痛特性的局部作用的非甾体抗炎药。与前列腺素合成酶选择性结合，并具有显着的体外抗菌活性。 了解更多
  11. MRT67307
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    MRT67307

    Catalog No. A11485
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    SIK/TBK-1/IKKe 抑制剂
    MRT67307是一种强效双IKK?和TBK1抑制剂，IC50分别为160和19 nM。 了解更多
  12. ARN-3236
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    ARN-3236

    Catalog No. A18725
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    SIK2 inhibitor
    ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. 了解更多
  13. YKL-06-061
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    YKL-06-061

    Catalog No. A18836
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    SIK inhibitor
    YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor. 了解更多
  14. HG-9-91-01
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    HG-9-91-01

    Catalog No. A21004
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    SIK inhibitor
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. 了解更多
  15. BEC HCl
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    BEC HCl

    Catalog No. A15881
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    arginase 抑制剂
    BEC HCl是一种缓慢结合的竞争性精氨酸酶抑制剂，精氨酸酶II和大鼠精氨酸酶I的Ki分别为0.31 μM（pH7.5）和0.4-0.6 μM。 了解更多
  16. CB-1158
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    CB-1158

    Catalog No. A16929
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    Arginase 抑制剂
    CB-1158，也称为INCB01158，是一种有效的口服活性精氨酸酶抑制剂，IC50 = 89nM。 了解更多
  17. CB-1158
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    CB-1158

    Catalog No. A16864
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    arginase 抑制剂
    CB-1158，也称为INCB01158，是一种有效的口服精氨酸酶抑制剂，IC50 = 89 nM。 了解更多
  18. nor-NOHA acetate
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    nor-NOHA acetate

    Catalog No. A21673
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    Arginase inhibitor
    nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. 了解更多
  19. Arginase inhibitor 1
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    Arginase inhibitor 1

    Catalog No. A21007
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    arginases I and II inhibitor
    Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. 了解更多
  20. AT 56
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    AT 56

    Catalog No. A13032
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    L-PGDS 抑制剂
    AT-56是脂环素型前列腺素D合酶（L-PGDS）的口服活性抑制剂（Ki = 75μM，IC50 = 95μM）。 了解更多
  21. HPGDS inhibitor 1
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    HPGDS inhibitor 1

    Catalog No. A12258
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    HPGDS 抑制剂
    HPGDS inhibitor 1是一种新的选择性造血前列腺素d合酶(HPGDS)抑制剂，IC50值为0.7 nM。 了解更多
  22. SAR191801
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    SAR191801

    Catalog No. A14444
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    hPGDS 抑制剂
    SAR191801是一种hPGDS抑制剂，在荧光偏振分析或EIA分析中，IC50为12 nM。 了解更多
  23. HPGDS inhibitor 2
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    HPGDS inhibitor 2

    Catalog No. A18390
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    H-PGDS 抑制剂
    HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM. 了解更多
  24. Apocynin (Acetovanillone)
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    Apocynin (Acetovanillone)

    Catalog No. A11989
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    NADPH-oxidase 抑制剂
    Apocynin (Acetovanillone)是NADPH氧化酶抑制剂。 了解更多
  25. ML 171
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    ML 171

    Catalog No. A13360
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    NOX1 抑制剂
    ML 171是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 了解更多
  26. GKT137831
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    GKT137831

    Catalog No. A14433
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    NOX1/4 抑制剂
    GKT137831是针对NOX1和NOX4酶的一流抑制剂。 了解更多
  27. APX-115
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    APX-115

    Catalog No. A18737
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    Nox inhibitor
    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury. 了解更多
  28. GSK2795039
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    GSK2795039

    Catalog No. A20998
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    NOX2 inhibitor
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis. 了解更多
  29. PD1-PDL1 inhibitor 2
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    PD1-PDL1 inhibitor 2

    Catalog No. A15906
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    PD-1/PD-L1 interaction 抑制剂
    PD1-PDL1 inhibitor 2 是PD-1/PD-L1相互作用抑制剂。 了解更多
  30. PD1-PDL1 inhibitor 1
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    PD1-PDL1 inhibitor 1

    Catalog No. A15882
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    PD1-PDL1 inhibitor 1 是PD-1/PD-L1相互作用抑制剂。 了解更多
  31. MI 2
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    MI 2

    Catalog No. A12928
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    MALT1 抑制剂
    MI 2直接与MALT1结合并在体外和体内抑制活化的B细胞样弥漫性大B细胞淋巴瘤（ABC-DLBCL）。 了解更多
  32. MLT-748
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    MLT-748

    Catalog No. A18954
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    MALT1 inhibitor
    MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. 了解更多
  33. MLT-747
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    MLT-747

    Catalog No. A18942
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    MALT1 inhibitor
    MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM. 了解更多
  34. Pranlukast (ONO 1078)
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    Pranlukast (ONO 1078)

    Catalog No. A11908
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    Pranlukast (ONO 1078)是一种选择性的半胱氨酰白三烯受体拮抗剂。 了解更多
  35. MK-0679 (Verlukast)
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    MK-0679 (Verlukast)

    Catalog No. A11607
    LTD4 receptor 拮抗剂
    MK-0679 (Verlukast)是有效的白三烯D4拮抗剂。 了解更多
  36. LY 255283
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    LY 255283

    Catalog No. A13090
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    BLT2 receptors 拮抗剂
    LY 255283是一种有效的 BLT2 receptors 拮抗剂。 了解更多
  37. MK-571
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    MK-571

    Catalog No. A12529
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    CysLT1 receptor 拮抗剂
    MK-571是有效的CysLT1（LTD4）白三烯受体反向激动剂，EC50值为1.3 nM。 了解更多
  38. MK-571 sodium salt
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    MK-571 sodium salt

    Catalog No. A15983
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    CysLT1 receptor 拮抗剂
    MK-571 sodium salt是一种选择性的口服活性CysLT1受体拮抗剂。它阻断LTD4而不是LTC4与人和豚鼠肺膜的结合，Ki值分别为0.22 nM和2.1 nM。 了解更多
  39. Montelukast
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    Montelukast

    Catalog No. A17780
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    LTR antagonist
    Montelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. 了解更多
  40. AS-35
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    AS-35

    Catalog No. A19409
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    LTR antagonist
    AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. 了解更多
  41. RTA-408
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    RTA-408

    Catalog No. A14417
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    Nrf2 抑制剂
    RTA-408是一种合成的三萜类化合物，可有效激活抗氧化转录因子Nrf2并抑制促炎转录因子NF-kB。 了解更多
  42. Brusatol
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    Brusatol

    Catalog No. A16893
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    Nrf2 抑制剂
    Brusatol是一种生化物质，从Brucea javanica植物中分离出来，可抑制Nrf2。 了解更多
  43. ML-385
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    ML-385

    Catalog No. A17172
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    NRF2 抑制剂
    ML-385是核因子红系2相关因子2（Nrf2）的抑制剂，IC50值为1.9μM。 了解更多
  44. Oltipraz
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    Oltipraz

    Catalog No. A13164
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    Nrf2 activator
    Oltipraz抑制HIF-1alpha活性和HIF-1alpha依赖性肿瘤生长，这可能是由于S6K1抑制结合H2O2清除作用导致HIF-1alpha稳定性降低所致。 了解更多
  45. CDDO-EA
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    CDDO-EA

    Catalog No. A16299
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    Nrf2 activator
    CDDO-EA是Nrf2/ARE的激活剂；神经保护作用。 了解更多
  46. NK-252
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    NK-252

    Catalog No. A16300
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    Nrf2 activator
    NK-252是Nrf2活化剂，与OPZ相比，具有更大的Nrf2活化电位。 了解更多
  47. AKBA
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    AKBA

    Catalog No. A17908
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    Nrf2 activator
    AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. 了解更多
  48. Nrf2-IN-1
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    Nrf2-IN-1

    Catalog No. A12561
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    Nrf2 inhibitor
    Nrf2-IN-1 (Compound 4f) is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), acts as a promising agent in acute myeloid leukemia (AML) therapy. 了解更多
  49. (R)-Sulforaphane
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    (R)-Sulforaphane

    Catalog No. A21690
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    Keap1/Nrf2/ARE pathway inducer
    (R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. 了解更多
  50. Diphenyleneiodonium chloride
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    Diphenyleneiodonium chloride

    Catalog No. A13359
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    GPR3 激动剂/NOS/ NADPH oxidases 抑制剂
    Diphenyleneiodonium是一种有效的不可逆的巨噬细胞抑制剂NOS2（iNOS）和内皮细胞NOS3（eNOS）抑制剂。 了解更多

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分类
  1. IL Receptor (11)
  2. COX (64)
  3. CCR (29)
  4. Toll-like Receptors (19)
  5. CXCR (30)
  6. ROS (6)
  7. NOS (6)
  8. Keap1-Nrf2 (9)
  9. LTR (7)
  10. MALT (3)
  11. PD-1/PD-L1 (2)
  12. NADPH oxidase (6)
  13. PGE Synthase (4)
  14. Arginase (5)
  15. Salt-inducible Kinase (SIK) (4)
  16. Immunology & Inflammation related (11)
作用机制
  1. Inhibitor (抑制剂) (115)
  2. Agonist (激动剂) (18)
  3. Antagonist (拮抗剂) (50)
  4. Activator (激活剂) (6)
  5. Modulator (调节剂) (3)
靶点
  1. 5-lipoxygenase (1)
  2. COX (13)
  3. COX-1 (13)
  4. COX-2 (23)
  5. CXCL12 (1)
  6. CXCL8 (2)
  7. CXCR1 (4)
  8. CXCR2 (9)
  9. CXCR4 (11)
  10. Histamine H1 receptor (1)
  11. HSP90 (1)
  12. LOX (1)
  13. Src (1)
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