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Immunology & Inflammation

产品 151 到 200 共 214个

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  1. Licofelone
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    Licofelone

    Catalog No. A11697
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    COX/LOX 抑制剂
    Licofelone是一种COX/LOX双重抑制剂，被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX（环氧合酶）的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。 了解更多
  2. Diclofenac sodium
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    Diclofenac sodium

    Catalog No. A10304
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    COX 抑制剂
    Diclofenac Sodium是一种非选择性的COX抑制剂，完整细胞中的COX-1和-2的IC50分别为0.5μg/ml和0.5μg/ml，作用于绵羊COX-1和COX-2， IC50分别为60和220 nM，用作非甾体类抗炎药（NSAID）来减轻疼痛和减轻疼痛 肿胀发炎。 了解更多
  3. ATB-337
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    ATB-337

    Catalog No. A11986
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    ATB-337是H2S供体和NSAID双氯芬酸的杂合分子。 了解更多
  4. Rofecoxib (Vioxx)
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    Rofecoxib (Vioxx)

    Catalog No. A11918
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    COX-2 抑制剂
    Rofecoxib (Vioxx)是一种COX-2抑制剂，IC50值为18 nM。 了解更多
  5. Phenacetin
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    Phenacetin

    Catalog No. A11906
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    Phenacetin是一种非阿片类镇痛药，无抗炎特性。 了解更多
  6. Indomethacin (Indocid, Indocin)
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    Indomethacin (Indocid, Indocin)

    Catalog No. A10474
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    COX 抑制剂
    Indomethacin (Indocid, Indocin)是一种非选择性COX1和COX2抑制剂，IC50分别为0.1 μg/mL和5 μg/mL。吲哚美辛(吲哚满，吲哚满)是一种非甾体抗炎药，通常用于减轻发热、疼痛、僵硬和肿胀。 了解更多
  7. Phenylbutazone (Butazolidin, Butatron)
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    Phenylbutazone (Butazolidin, Butatron)

    Catalog No. A10720
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    COX 抑制剂
    Phenylbutazone (Butazolidin,Butatron)是一种具有研究意义的化合物，它是一种抗炎和抗增殖剂。 了解更多
  8. Piroxicam (Feldene)
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    Piroxicam (Feldene)

    Catalog No. A10736
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    COX 抑制剂
    Piroxicam (Feldene)是前列腺素合成的有效抑制剂，并且是Cox-1和Cox-2抑制剂。 了解更多
  9. Iguratimod (T 614)
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    Iguratimod (T 614)

    Catalog No. A11464
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    COX-2 抑制剂
    Iguratimod (T 614)是一种抗风湿剂，能够有效地抑制COX-2的活性，IC50值为20 μM (7.7 μg/mL)，而对 COX-1 无作用；Iguratimod同时为巨噬细胞移动抑制因子 (MIF) 抑制剂，IC50值为6.81 μM。 了解更多
  10. Jaceosidin
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    Jaceosidin

    Catalog No. A12080
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    Jaceosidin是一种来源于艾蒿的药理活性黄酮，通过阻断培养的人乳腺上皮细胞中erk-1和-2的磷酸化来抑制佛波酯诱导的cox-2和MMP-9的上调。 了解更多
  11. (S)-(+)-Flurbiprofen
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    (S)-(+)-Flurbiprofen

    Catalog No. A12434
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    COX 抑制剂
    (S)-(+)-Flurbiprofen是一种非选择性的Cox-1和Cox-2抑制剂。 了解更多
  12. NS-398
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    NS-398

    Catalog No. A13116
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    COX-2 抑制剂?
    NS-398是具有镇痛和解热作用的非甾体类抗炎药，可选择性抑制前列腺素G / H合酶2 /环氧合酶2（COX-2）活性，IC50为3.8μM，对COX无影响 了解更多
  13. Bromfenac sodium
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    Bromfenac sodium

    Catalog No. A13244
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    COX-2 抑制剂
    Bromfenac sodium是一种局部选择性环氧合酶(COX)-2抑制剂 了解更多
  14. Acetaminophen
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    Acetaminophen

    Catalog No. A10030
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    COX 抑制剂
    Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。 了解更多
  15. Naproxen sodium
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    Naproxen sodium

    Catalog No. A10623
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    COX 抑制剂
    Naproxen sodium是一种非选择性的环氧合酶（COX）抑制剂，具有抗炎，解热和镇痛作用。对秋水仙碱引起的认知障碍和氧化应激具有神经保护作用。 了解更多
  16. FK 3311
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    FK 3311

    Catalog No. A13332
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    COX-2 抑制剂
    FK3311是一种可渗透细胞且可口服的磺酰苯胺，可作为选择性COX-2抑制剂和NSAID。 了解更多
  17. Valdecoxib
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    Valdecoxib

    Catalog No. A13342
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    COX-2 抑制剂
    伐地考昔（Valdecoxib），也称为SC-65872，是一种非甾体类抗炎药（NSAID），用于治疗骨关节炎，类风湿性关节炎以及痛经和月经症状。 它是一种选择性的环氧合酶2（COX-2)抑制剂,IC50为5nM。 了解更多
  18. Parecoxib
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    Parecoxib

    Catalog No. A13572
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    COX-2 抑制剂
    Parecoxib是一种有效的选择性COX-2抑制剂。 了解更多
  19. Fenbufen
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    Fenbufen

    Catalog No. A16002
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    Fenbufen是一种具有消炎，镇痛和解热活性的口服活性苯基链烷酸衍生物。 了解更多
  20. Diflunisal
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    Diflunisal

    Catalog No. A16166
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    COX 抑制剂
    Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。 了解更多
  21. Amfenac Sodium Monohydrate
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    Amfenac Sodium Monohydrate

    Catalog No. A16399
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    COX 抑制剂
    Amfenac Sodium Monohydrate是一种非甾体止痛消炎药，带有乙酸部分。COX1和COX2的IC50值分别为250 nM和150 nM。 了解更多
  22. Ampiroxicam
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    Ampiroxicam

    Catalog No. A16409
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    COX 抑制剂
    Ampiroxicam是一种非选择性的环氧合酶抑制剂，被用作抗炎药。 了解更多
  23. Carprofen
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    Carprofen

    Catalog No. A16428
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    COX-2 抑制剂
    Carprofen通过抑制COX-2和其他炎症性前列腺素来减轻炎症，不干扰COX-1活性。 了解更多
  24. Timegadine
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    Timegadine

    Catalog No. A17108
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    COX and lipo-oxygenase 抑制剂
    Timegadine被发现是一种有效的竞争性环加氧酶（COX）和脂加氧酶抑制剂，IC50的范围从5 nM（洗兔血小板）到20μM（大鼠脑）。在马血小板匀浆的细胞溶质级分和洗涤过的兔血小板中，脂氧化酶的浓度为100μM和100μM。 了解更多
  25. Ketorolac
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    Ketorolac

    Catalog No. A17248
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    COX 抑制剂
    Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. 了解更多
  26. Firocoxib
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    • 最新产品

    Firocoxib

    Catalog No. A17245
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    COX-2 抑制剂
    Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. 了解更多
  27. Aceclofenac
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    Aceclofenac

    Catalog No. A17433
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    COX-2 抑制剂
    Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. 了解更多
  28. Naproxen
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    Naproxen

    Catalog No. A17550
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    COX 抑制剂
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  29. Imrecoxib
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    Imrecoxib

    Catalog No. A18027
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    COX-2 抑制剂
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. 了解更多
  30. Deracoxib
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    Deracoxib

    Catalog No. A18077
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    NSAID and COX-2 抑制剂
    Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. 了解更多
  31. Bromfenac sodium hydrate
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    Bromfenac sodium hydrate

    Catalog No. A18194
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    COX-2 抑制剂
    Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2). 了解更多
  32. Metamizole sodium hydrate
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    Metamizole sodium hydrate

    Catalog No. A18270
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    COX 抑制剂
    Dipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). 了解更多
  33. Radicicol
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    Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 抑制剂
    Radicicol是Hsp90，SRC和Cox-2的有效抑制剂。 了解更多
  34. Fexofenadine HCl
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    Fexofenadine HCl

    Catalog No. A11859
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    COX 抑制剂/histamine H1 receptor 激动剂
    Fexofenadine Hydrochloride是一种抗组胺药，可抑制Cox-1，Cox-2，并且是组胺H1受体激动剂，IC50为246 nM。 了解更多
  35. Tepoxalin
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    Tepoxalin

    Catalog No. A12879
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    COX/5-LOX 抑制剂
    Tepoxalin是花生四烯酸代谢的双重环氧合酶/5-脂氧合酶抑制剂，具有有效的抗炎活性和良好的胃肠道功能。 了解更多
  36. Flufenamic acid
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    Flufenamic acid

    Catalog No. A13333
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    COX 抑制剂
    Flufenamic acid是一种非甾体类抗炎药（NSAID）。抑制钙激活的氯离子通道（CaCC）。也增加通过TRPC6通道的电流，并抑制通过TRPC3和TRPC7通道的电流。 了解更多
  37. Pranoprofen
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    Pranoprofen

    Catalog No. A11641
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    COX 抑制剂
    Pranoprofen是一种用于眼科的非甾体类抗炎药。 了解更多
  38. (-)-Epicatechin
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    (-)-Epicatechin

    Catalog No. A12043
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    COX-1 抑制剂
    (-)-Epicatechin是绿茶的天然产物。(-)表儿茶素是cox-1的抑制剂。 了解更多
  39. ATB 346
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    ATB 346

    Catalog No. A13983
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    COX-2 抑制剂
    ATB-346具有类似于萘普生的抗炎特性，但其胃肠道毒性显着降低。 了解更多
  40. Meclofenamate Sodium
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    Meclofenamate Sodium

    Catalog No. A12520
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    COX 抑制剂
    Meclofenamate Sodium是一种双重COX-1/COX-2抑制剂，IC50为40 nM和50 nM。 了解更多
  41. Paradol
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    Paradol

    Catalog No. A15205
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    COX-1 抑制剂
    Paradol是几内亚胡椒（Aframomum melegueta）种子的活性风味成分。已发现Paradol具有抗氧化和抗肿瘤的促进作用。 了解更多
  42. Etoricoxib
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    Etoricoxib

    Catalog No. A13770
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    COX-2 抑制剂
    Etoricoxib特异性结合并抑制环氧合酶2（COX-2），从而抑制花生四烯酸向前列腺素的转化。抑制COX-2可以诱导细胞凋亡并抑制肿瘤细胞的增殖和血管生成。 了解更多
  43. Xanthohumol
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    Xanthohumol

    Catalog No. A15919
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    COX 抑制剂
    Xanthohumol是一种来自啤酒花的烯丙基查尔酮，可抑制COX-1和COX-2活性并显示化学预防作用。 了解更多
  44. SC 560
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    SC 560

    Catalog No. A13023
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    COX-1 抑制剂
    SC 560是一种COX-1选择性抑制剂，IC50 值为9 nM。可以用作研究COX-1衍生的PG在炎症和疼痛中的作用的药理学工具。 了解更多
  45. Etodolac (AY-24236)
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    Etodolac (AY-24236)

    Catalog No. A10371
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    COX inhibitor
    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). 了解更多
  46. Tenidap
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    Tenidap

    Catalog No. A13340
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    COX-1 inhibitor
    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. 了解更多
  47. GW-406381
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    GW-406381

    Catalog No. A19118
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    COX-2 inhibitor
    GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. 了解更多
  48. Eicosatetraynoic acid
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    Eicosatetraynoic acid

    Catalog No. A19008
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    COX/LOX inhibitor
    Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? 了解更多
  49. Aspirin
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    Aspirin

    Catalog No. A11797
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    COX-1/COX-2 inhibitor
    Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. 了解更多
  50. Naproxen etemesil
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    Naproxen etemesil

    Catalog No. A13052
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    COX-1 and COX-2 inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多

产品 151 到 200 共 214个

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购物选项

分类
  1. IL Receptor (11)
  2. COX (64)
  3. CCR (29)
  4. Toll-like Receptors (19)
  5. CXCR (30)
  6. ROS (6)
  7. NOS (6)
  8. Keap1-Nrf2 (9)
  9. LTR (7)
  10. MALT (3)
  11. PD-1/PD-L1 (2)
  12. NADPH oxidase (6)
  13. PGE Synthase (4)
  14. Arginase (5)
  15. Salt-inducible Kinase (SIK) (4)
  16. Immunology & Inflammation related (11)
作用机制
  1. Inhibitor (抑制剂) (115)
  2. Agonist (激动剂) (18)
  3. Antagonist (拮抗剂) (50)
  4. Activator (激活剂) (6)
  5. Modulator (调节剂) (3)
靶点
  1. 5-lipoxygenase (1)
  2. COX (13)
  3. COX-1 (13)
  4. COX-2 (23)
  5. CXCL12 (1)
  6. CXCL8 (2)
  7. CXCR1 (4)
  8. CXCR2 (9)
  9. CXCR4 (11)
  10. Histamine H1 receptor (1)
  11. HSP90 (1)
  12. LOX (1)
  13. Src (1)
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