Immunology & Inflammation
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COX inhibitor
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor.
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COX inhibitor
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.
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COX-2 inhibitor
Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
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Suplatast Tosilate是一种新型的胶囊抗哮喘药,可抑制IgE产生,IL-4和IL-5合成,IC50高于100μM。
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IL-17 抑制剂
Y320是一种免疫调节剂,可抑制IL-15刺激的CD4 T细胞产生IL-17,IC50为20至60 nM。
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gp130 抑制剂
SC-144是活性小分子gp130抑制剂。
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IL-12/IL-23 inhibitor
Apilimod is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?Cstimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.
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T cell activator
beta-Interleukin I (163-171), human是一组细胞因子(分泌的蛋白质/信号分子),最初被认为是由白细胞(白细胞)表达的。
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NLRP3 抑制剂
MCC950 sodium是一种有效的NLRP3炎性体抑制剂,可抑制IL-1beta的产生,IC50值为7.5 nM。
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interleukin-5 receptor 拮抗剂
YM-90709是白介素5受体拮抗剂。YM-90709抑制IL-5与其周围人嗜酸性粒细胞和丁酸处理的嗜酸性HL-60克隆15细胞的受体结合,IC50值分别为1.0和0.57 microM。
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IL-12/23 抑制剂
APY0201是有效的选择性IL-12/23抑制剂。
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IL-1 抑制剂
AS101是一种有效的体外和体内免疫调节剂,是一种新型的IL-1beta转化酶抑制剂。
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IL-1 receptor 拮抗剂
AF 12198是人I型白介素1(IL-1)受体的有效选择性拮抗剂。
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IL-1 receptor-associated kinase (IRAK) kinase modulator
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
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