INK 128 (MLN0128)

Name: INK 128 (MLN0128)
SKU: A11461

目录号: A11461

mTOR 抑制剂

Product Citations (1)

INK 128 (MLN0128) Chemical Structure

CAS NO. 1224844-38-5

INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 560.00
10 mg	￥ 700.00
25 mg	￥ 1,260.00
50 mg	￥ 1,750.00
10mM * 1mL in DMSO	￥ 560.00

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生物活性

INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。

Targets

Target	Value
mTOR	ki: 1.4nM
mTOR	ki: 1.4nM
PI3Kα	IC50: 219nM
PI3Kγ	IC50: 221nM
PI3Kδ	IC50: 230nM
PI3Kβ	IC50: 5293nM

溶解度 *

In vitro (25°C)	DMSO	58 mg/mL (187.5 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (6.46 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.33 mL	161.66 mL	323.31 mL
0.5 mM	6.47 mL	32.33 mL	64.66 mL
1 mM	3.23 mL	16.17 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL

*The above data is based on the productmolecular weight 309.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11461
作用机制	Inhibitor (抑制剂)
M. Wt	309.3
Formula	C15H15N7O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1224844-38-5
Synonyms	INK128, INK-128
SMILES	CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N