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IOX2是一种有效的HIF-1α脯氨酰羟化酶2（PHD2）抑制剂，在无细胞分析中的IC50为21 nM，选择性是JMJD2A，JMJD2C，JMJD2E，JMJD3或2OG加氧酶FIH的100倍以上。
靶点信息
| PHD2 (Cell-free assay) | ||||
| 21 nM |
| In vitro (25°C) | DMSO | 7 mg/mL (19.86 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.38 mL | 141.92 mL | 283.85 mL |
| 0.5 mM | 5.68 mL | 28.38 mL | 56.77 mL |
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
*The above data is based on the productmolecular weight 352.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11924 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 352.3 |
| Formula | C19H16N2O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 931398-72-0 |
| Synonyms | IOX-2, IOX2 |
| SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O |
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